ID   A0A452HM78_9SAUR        Unreviewed;      1147 AA.
AC   A0A452HM78;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
OS   Gopherus agassizii (Agassiz's desert tortoise).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Testudinidae; Gopherus.
OX   NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000016037.1, ECO:0000313|Proteomes:UP000291020};
RN   [1] {ECO:0000313|Proteomes:UP000291020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28562605;
RA   Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA   Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT   "The Agassiz's desert tortoise genome provides a resource for the
RT   conservation of a threatened species.";
RL   PLoS ONE 12:e0177708-e0177708(2017).
RN   [2] {ECO:0000313|Ensembl:ENSGAGP00000016037.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC       subfamily. {ECO:0000256|ARBA:ARBA00008921}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A452HM78; -.
DR   Ensembl; ENSGAGT00000018320.1; ENSGAGP00000016037.1; ENSGAGG00000011475.1.
DR   Proteomes; UP000291020; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR010457; IgC2-like_lig-bd.
DR   InterPro; IPR041182; LEP-R_IGD.
DR   PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR23037:SF37; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF06328; Lep_receptor_Ig; 1.
DR   Pfam; PF18589; ObR_Ig; 2.
DR   SMART; SM00060; FN3; 3.
DR   SUPFAM; SSF49265; Fibronectin type III; 4.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        823..845
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          222..316
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          523..619
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          724..817
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          940..959
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1147 AA;  130360 MW;  173E3D5104E6F7D2 CRC64;
     VYHQNFMQMA VAHCMVHQIP ASSFMLPCMS PNETSVIPLT AGVVASSPGL HREHGTTETN
     SLMLVAEESF LCCLWSETNA NCSLYTAGME TKKFTSSEVS SFAPQQTDLS WNIQCWTKGD
     LELFVCILKL SNKKSYLNGE FKINLLYVLS ELSLEDISTG SLKGNFMVTP CNGNGSDKYE
     CHIPSLKLNY TYITWLNIIN GVTLLQSPLM SVRPINIVKP ESPLNLRLEM TDKGQLKICW
     SNPVLTPYPL QYEVKFSGNT TQNAWQVVEI VIETSLIIGN MLVGSSYLVQ VRCKSLHGTG
     FWSDWSTPYN LNTEDVMYFP PKILTSVGSN VSFHCLYNDK NKMILSKKIV WWLNLAEEIP
     ERQYTLVNDR VSRVTLFNLN ATKPRGKFFY NALYCCNQNR ECHHRYAELY VVDVNINITC
     ETDGYLTKMT CRWSANTNTL LVGSSLQLKY YRSSIYCSDF PSIPPKSEAK ECHLQRNHYY
     ECTFQPIFLL SGYTMWIEIK HQLGTLESPP TCVIPADVVK PFPPSNVKAE ITKNIGLLNV
     SWTNPAFPNS DLKFQIRYSV NREEILWEIF EVSNAPTRSV MIKVLDLCVV YIVQVRCSGL
     DGLGYWSDWS KPAYTIVQDI QAPLRGPEFW RVINEDPIRK QKNVTLVWKP LMKNYSLCSV
     CGYIVKQHTS ENITWTEYVT SGTTYTYPWM EDAHTITILA VNSVGASSMN FNLTLSQQMS
     TVNIVQSLSA YPVNSSCVIL TWTLSPQMYV ITSFVIEWKN LNEEEQMKWI RVAPNISKYY
     IYDHFILIEK YQFSLYPIFP EGVGNPKTTD EFIKDRSEKQ NDAGLYVILP IVISSFVLLL
     GTLLISQQRM KKLFWEDVPN PKNCSWAQGV NFQKPETFEH LFIKHPEAIS FGPLLLEPEI
     VLEDISVAKA LKSEDKQDLL AVDSMFTMIQ DSEHDSACSS SHFSNSLSES SHDDKVSERT
     MRQSNIKYAT IISNCKLSGL YEEQKNLSGS FSGCFLGEDS LVIDPFSRSW EVGNQAFLIL
     PDQHPSQASK TISLSVVSSE GFSEPSDHDD TFSDGDSPER SLYYLGLTSV KKNENDIFLT
     ENSRVMCHLH TNGLFKDMGF LQDTSSDLNP FIKNSLKYEN SVKTFVPYMP QFQATTIKLQ
     ETTETKT
//