ID A0A452HSW0_9SAUR Unreviewed; 508 AA.
AC A0A452HSW0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000018152.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000018152.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-
CC glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00000251,
CC ECO:0000256|RuleBase:RU610713};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC {ECO:0000256|ARBA:ARBA00008871, ECO:0000256|RuleBase:RU610713}.
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DR AlphaFoldDB; A0A452HSW0; -.
DR STRING; 38772.ENSGAGP00000018152; -.
DR Ensembl; ENSGAGT00000020690.1; ENSGAGP00000018152.1; ENSGAGG00000013446.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR018155; Hyaluronidase.
DR PANTHER; PTHR11769; HYALURONIDASE; 1.
DR PANTHER; PTHR11769:SF19; HYALURONIDASE-3; 1.
DR Pfam; PF01630; Glyco_hydro_56; 1.
DR PRINTS; PR00846; GLHYDRLASE56.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU610713};
KW Hydrolase {ECO:0000256|RuleBase:RU610713};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
SQ SEQUENCE 508 AA; 57981 MW; A5B072CCA6965736 CRC64;
MLGRGVHSGR KQEGVWTGRS CRTSTMTLGL TVWPWVLFCL GAILPSSSRG RSWESASASP
LLQHEPFVVV WNLPTARCHQ RFGVALPLED YAIVENQGNA FQGQNMTIFY KNKFGLYPYI
SPEGKYYNGG IPQKVRLKQH LERATAEITQ LLQPDFHGLA VVDWEEWRPL WRRNWGPKAV
YKEASEQWVW ERFPDMRAKK RVYLAEVEFE GAAQELMERT LELGKELRPW GLWGFYKFPD
CFNDNWMKGG NYSGECNAME VLRNNRLMWL WEASTALYPS IYLPPKLPPA KRQSYVHHRL
QEAFRVARFG LEQPLSVIAY SRVSYRHSTR YLSEADLVHT IGESAALGAT GLALWGDNSY
SRSAESCRSL RHYITHTLGP YVVNVTSAAQ LCSRQLCHGH GRCVRQRPDE LGAFLHLSLQ
QWGADPVLTN YVGMDEPGQR AWGQFCCRCY RGWTGASCEK PGWTEPIRSP DCIARAHHPD
ICVAVRDRNT AGSQICPKSA YEGKTELR
//
