ID A0A452HU17_9SAUR Unreviewed; 349 AA.
AC A0A452HU17;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Major facilitator superfamily domain containing 2B {ECO:0008006|Google:ProtNLM};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000018595.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000018595.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452HU17; -.
DR STRING; 38772.ENSGAGP00000018595; -.
DR Ensembl; ENSGAGT00000021200.1; ENSGAGP00000018595.1; ENSGAGG00000013757.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR039672; MFS_2.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11328; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11328:SF30; SPHINGOSINE-1-PHOSPHATE TRANSPORTER MFSD2B; 1.
DR Pfam; PF13347; MFS_2; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..349
FT /note="Major facilitator superfamily domain containing 2B"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019399360"
FT TRANSMEM 100..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 349 AA; 38106 MW; 35DE9D8807C3A839 CRC64;
MFTLNVLHFL LSVLVLFQLR QEDRLSVCSK LCYAIGGAPN QVATSATAFF LQIYLLDIAH
ITPFHASLVL FIGKAWGAVT DPVAGFFISK SKWTKIGRLM PWMLGCTPFT IVSYFFMWYL
PPFVAGRVVW YLTFYCLFQA LTTLFQVPYS ALTMFLSPDQ KERDSATAYR MTVEVLGTLM
GAALHGQIVA SAHASDRCAV NLTINAADSS SSLSNASNLA EPLGLQSHGR EVYMIAAGVI
GGVYLFGIVI LFAGVKERDG KLNSNTSGFQ SDSFPLSFGK YDIILCIPPL VDPYALNSDK
AIPFFKGLRL TMKHGPYLKL TASFLLISTA VQVTPVFASP CIGLVLPTA
//
