ID A0A452HUE9_9SAUR Unreviewed; 1315 AA.
AC A0A452HUE9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000018749.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000018749.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSGAGT00000021372.1; ENSGAGP00000018749.1; ENSGAGG00000013870.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT DOMAIN 367..554
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1171..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 537..568
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 22..39
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1181..1195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1221..1240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1315 AA; 147308 MW; 69E7CE5F65030050 CRC64;
MEAEDFPPPP PEVLENELKG CGTNDEEEEE GEQFDFDSGD EIPEADRQAL VPSASDSGIN
VEHEDTNSTG DDNIGRTEKI QTTESCAESS PTKVNPYSVI NISPIQEKDH SSSPEPNPQD
ENASSNLSGG YSVPVPCGYA VPSNLPLMLP AYSSPIIIRS VSVDEEVGMQ SVTEDGNSNS
LSSEDPPNSE DNQVCKEEDA LAKWVADPAN TSWMENPDEV IYDDVPKEDS DTEPEEMIYD
DVENGDDGGN SSLEYGWSSS EFESYEEQSD SECKDGFPSS FLRGNHKRQM QKLMRAAREG
TKDGYEKTKA AVKKGRSFIR TKSFITQDHK SSCMEEEELN LFIDVDCMHT EAIMTPMPEG
LSQQQVVRRY ILGSVVDSEK NYVDALKRIL EQYEKPLSEM EPKLLSERKL KMVFYRIKEI
LQCHSMFQIA LASRVSEWDS VEMIGDVFVA SFSKSMVLDA YSEYVNNFST AVGILKKTCA
TKPAFLDFLK QCQELSPDRI TLYGLMMKPI QRFPQFILLL QDMLKNTTKG HPDRLPLQMA
LTELETLAEK LNERKRDADQ RCEIKQIAKA MNERYLNKLL SSGNRYLIRT DDMIETVYNE
KGEIVKTKER RLFMLNDVLM CATVSARSSY ESSGIMATGL RYLLKWSVPL GQVEVIEYGS
NEGQGENCRF PPQHSAENVI VNVKPNKLYM GPGQLYHDLQ NLLHDLNVVS QISQLICSLK
GNYQNLNQSV AHDWTSGLQK LILKKEDEIR AADRCRIQLQ LPGKQDKSGR PTFFTAVFNT
FTPAIKQSWI TNLQMAKLAL AEENLLGWFC VEDDGNHIKR EKHPLLVRHM PVMVAKQQEF
KIECVTYNPD PYLCSETESD SCSMEHGFLW IGSCTNQMGQ IAIVSFQNSS PKVIECFNVE
SRILCMVYIP EEEKQKELNV APESENMATK TLKVPTVCLG MEEGSISIYK SHQGSKKVRL
QHFFTPEKST VMSLTYLSQY LFAGLVNGNI AIYTKAEDGA WNSEPQKVVK LGVLPVRSLL
MMEDTIWAAS GGQIFIISTE THTVERHFEA HQEEGMVISH MAVAGVGIWI AFTSGSTLRL
FHTETLKHLQ DINIATPVHN ILSGQQRISV TSLLVCHGLL LVGTNLGIIV ALPVPRLQGI
PKVTGRGMVS YHAHNGPVKF LVMVTAVNKK NKSKSRNSLP PNCEAKEDDQ KNVLHNDRPS
SFLSNTHDTA VWLGGSAGSI AQRSDKSSSS GSLTLSHGSN SLERRPEDST IYELLKDQNI
SLKNKRQRSR KMKASSVLVI SGGQGHRRVN KKSKQQRQDE LVSSVMVWQI PLLNI
//
