ID A0A452HWG9_9SAUR Unreviewed; 816 AA.
AC A0A452HWG9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000019507.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000019507.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR Ensembl; ENSGAGT00000022210.1; ENSGAGP00000019507.1; ENSGAGG00000013955.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF22; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 413..431
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 443..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 515..537
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 544..572
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 612..634
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 747..769
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 94..128
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 816 AA; 93880 MW; 0DC40271308AB1A8 CRC64;
MGSLFRSERM CLAQLFLQAG SAYECLSELG ERGLAEFRDL NPSVSVFQRK FVSEVKKCEE
MERILGFLVQ EIKKADIPLP EGDTAPAAPH LKNMLEIQEQ LQKLETELRE VTKNKEKLKK
NLLELTEYTY MLRITQAFVK RPVEEFPSLE NDPLVDYTCM HRLGAKLGFI SGLVHQAKIE
AFEKMLWRVC KGYTILTYAE LDECLEDPDT GEIRKWFVFL ISFWGEQIGQ KVKKICDCYH
CHVYPYPNTT EERRDVIEGL NVRIQDLHVV LHKTEDYLRQ VLCKASESIY TWVIQVKKMK
AIHHVLNQCS FDVTNKCLIA EVWCPVADLP NLRRALEEGS RKSGAAISSF MNTIPTTETP
PTLIRTNKFT SGFQNIVDAY GVGNYREVNP ALYTIITFPF LFAVMFGDFG HGLLMFIFAL
LMVLYXAVLQ YLQIMKMFFE GRYIILLMGL FSVYTGLIYN DCFSKSLNIF GSGWKISKSL
YGSLNPQIKI VLHPKLIWNL ASNRLSFLNS FKMKMSVIFG VTHMTFGVIL GVFNHLYFRK
RHNVYLVFLP ELLFMLCIFG YLVFIIIFKW LAYSAENSRS APSILIQFIN MFLFPTSGVD
TFYTGQVILQ RFLFIVALLS VPVMLFGKPL YLYWLHNGGR GIGMYRSGYR LVRKESEEEL
SLLRSHDVEE GSSPSDSGHR EGDGEEFNFA DVFMNQTIHT IEYCLGCISN TASYLRLWAL
SLAHAQLSEV LWAMIMRVGL RVDAEYGILL LLPVLAFFAV LTVFILLVME GLSAFLHAVR
LHWVEFQNKF YTGGGYKFTP FSFKHIFLHF NKDDIA
//