ID A0A452HZ03_9SAUR Unreviewed; 848 AA.
AC A0A452HZ03;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DEP domain-containing protein {ECO:0000259|PROSITE:PS50186};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000020469.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000020469.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSGAGT00000023315.1; ENSGAGP00000020466.1; ENSGAGG00000015076.1.
DR Ensembl; ENSGAGT00000023318.1; ENSGAGP00000020469.1; ENSGAGG00000015076.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd04443; DEP_GPR155; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR037368; GPR155_DEP.
DR InterPro; IPR004776; Mem_transp_PIN-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF5; INTEGRAL MEMBRANE PROTEIN GPR155; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF03547; Mem_trans; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 771..839
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 559..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 848 AA; 94745 MW; 7975924A1190B07B CRC64;
MDTFSDFTAK NLSSSANMSH SLPSHLDYQF NVTSHSPSMS ISRLFPALLQ CFGIILCGYI
AGRANIITSG QAKGLGNFVS CFALPALLFK NMVVLNFSNV NWSFLCSILV AKASVFFLVC
ILTLLVASPE SRFSKAGLFP IFATQSNDFA LGYPIVEALY QTTYPEYLQY IYLVAPISLM
MLNPIGFIFC EIQKWRDNRS MSHNKMKIVG LVLLRVLQNP IVFMVFIGIA SNFILGQKIP
VYLENFLDGL ASSFSGSALF YLGLSMVGQI KKLTKNAFVA LILLITAKLL MMPLFCREMV
ELLDKNDSLV NHTSLSNYAF LYGVFPAAPG VAIFANQFNM EVEIITSGMV ISTFVSAPIM
YVSAWLLTIP SMDPNPLASA IQNVSFDISI VSLVSLIWSL TVILLSKKYK QLPHMLTTNL
LIAQVVACIG MVIWNFIIRE RNITLQILVF MLLYSSLYST YLWTGFLSLT LLLLKKRDVI
KIPVGFIILA GWGIPTLLVG ILLITGERNT DSIDSAFFYG KYQMVTTAVT LFISILISGI
SLLCMNRNGQ ETDYEVLNPY SHNGQMENSE REGNEETQTS ISGSPPFVES SAERGWCSCQ
TINGELCCSG EGEPGSNATT NDSCTPPTET ANQCESQCSS ENCLLAQEEQ RLQSGDKQLA
RHVLLCLLLI VGLFANLSSC LWWLFNQEPG RLYVELQFFC AVFNFGQGFI SFGIFGLDKH
LIILPFKRRF EFLWGSREAV EHAESSVPEE IRMTCQQFVH YHRDVCVRSI VKDRRCGAKT
STGIFFGCEL VNWLIQVGLA SDRGEAVMYG DRLAKGGVIQ HITNEFEFQD EYLYYRFIRK
RSTVTKSH
//
