ID A0A452HZT2_9SAUR Unreviewed; 2405 AA.
AC A0A452HZT2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGAGP00000020702.1};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000020702.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000020702.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR STRING; 38772.ENSGAGP00000020702; -.
DR Ensembl; ENSGAGT00000023580.1; ENSGAGP00000020702.1; ENSGAGG00000015244.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1300..1321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1509..1528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1540..1567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1721..1747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1767..1789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1856..1878
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2115..2132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2152..2170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2190..2215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2236..2263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2298..2323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..1034
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1346..1463
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1663..1698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1664..1693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1955..1972
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 2405 AA; 273362 MW; ED3244E58166F84C CRC64;
MEQGPRISLS LTLRVEPALL HVLSAHSKLF SLPYQPLSLS WSLQPLGPRT LAYRLLDMQG
TEGWSASYNP YALRSNFCAD SMPRQASEMA LASIYFHVDG EWFGDLAGEL SFSNATLGLT
MNSETPTYLT LNAQKTKSGT YIFSRNHGLY YTTQANNASA PDDGVKSHYI FFQQQSLSFL
LTIEFVKLQW YKFNMHLYLN RKGALFRSLV DRDIEVHIFN SGPSFLQSLI YIVWFIPVQH
PMLQCEWTFN LQLFGSRKEY LIQNNTYTYD DHVRNAAHFV RRSVLPFNPA LYTGFVAKVN
CTRSGLTPAV LKVTVNTYAS KVMESLVSCQ KKPCFIERLR IQKPDLVYPI IRTKKGLQLI
LYAKLQVNCT DLVRTEAIWK IYGVQNVTTI PDWTKPLNPP LIWRRHMLIL QIPSFSLDYG
LYLFNFSVKI TASESVVEGS DTVFVQIEKS DLVAVIAGGT FRTVGFSDHW TLDGSTSSDP
DSLDRLEGLT FMWYCTKRVS DYANMTVSTN GTCHPNQVDL KWIKFSGPTQ TILPETLQGN
TVYHFRLVIQ KDNRKSYADQ TISVRPGSPP VLNVTCIENC GKIVIPTDRF TLSGKCLNCR
MTSRPVYHWS LFSGSFTEVK FDWASKTSTG KSSAYLSIHA LTFMNIADQS YSLLLKITTW
GGTSSTYRYS FYVNSPPRIG KCTVNPTRGV AFLTKFIVQC SGFSDKNLPL TYKVIAASDL
LKSSRITSLE ENTLGTIVYF GYQPKTPPSF LPIGVPSKKY TLTIYVQVYD SLGAFSQVAL
HTTVQDPAKS RPPDIMLNEL LALTSGSNAP MTSLLQIGDY LNVGYLVYMV ASILNDIKTA
PTIQVSKAEF RESLLNQSLS IPTTNVMEVN QVVACISELT QEVTEVNRAS QQLAIQKLKE
VSEALKRFRD KSLGSEQTEL LSTGILTGLS NVLKASLLDL SNVNVHAVKQ TFSVMETLAE
IVLQGKVPGE NETVMEAKSW NINLQKDEKW DVTNTFSAKK DCQNCFYPTL KQGDHSELPI
DAVIATVFYE FEENPFPWLA YTSDIVTTVT GFKMTGTKVN GDIIGIMPAV AEVIIARKDK
KSAAFKLTIG PDKTLPKTTG GFSFEVDRNS KDIFIQILTK LKVSFRLFIY LGVNVTHTSP
IASFVASHNE PAVASGNKSN NIDCAIKAPY VICLPQSLLR ATAPGSGTDK WTISIILQSQ
SIVRSRNNRL VSISLFNAVC LDLDGVQSQW KEGTCVLGPL TSWQRVHCIC KVKQRTKGTA
SRTIPSSSKF DIKFLASKVF VVPNPVDLKK SLLAKIHKNM VTLLTVLFIF LVYFLLALWA
LRKDRTDKVS RDKVIVLQDN DPFDKVCYLV TLYTGSRLGA GTTADVFLQL IGQNGTSDVH
HLRHLNYPSF IRGGIDTFLL TTKYDLGDIY SLRVWHNNGG SSPDWFLSRV KVENMYTKEF
WLFICRKWLA LDKDDRLLER TFVVTHPRVP LAKMDYFLIN IANDLVDSHI WLSVFAQVVT
GSFNRLQRLS CCLAVLLCTL LINIMFFNAD KNKEVVSIHL RYLISIIIGI ESALVTIPVQ
MIITALFKYS QKEPSPHGAA QNHPKESSPF MSGNLRNWKE RLQKWYITEA STQSVSSNTL
ENCSNANDSY SLQYFDKKRK QRTPKMWSNC TISEGAANAI AAQEENAADT STAEAKAQQT
QPRNSNFSNN YAEEKDDSIQ KERKPLNIPF MLFRKRPQIT FCWWCVYVSW ILVIAVAGVS
SFFIVLYGLS YGYKTSLEWL LASATSFFES VLLLQTLKII LFSALGTIYP KYYENIPWST
RDNFLEIRLD EVSMDADEMR EKHYEIIRLR GTKQYQPLEE DEITIMRKRE KIKSKVFIFL
KDIVSHFVFL TLVLNIAYST ENTNSFYYNQ VIHKQFSLKL SSVDKLEHIY LWVNNVFLSL
IHNNHQPTFL SDSWSKILGL PRMRQVRAKS TEKKCFHPHS FVNKFVISKS HCLHKYGSDP
EERGDYAGSW TKVANRSVTS DIVNYVGFTY QSNRNQWVYY SYGELYTYGP GGYTFYFFPA
EQRPNSTKRL NVLQNSNWLD EETWAVIIEL TTFNPDVHLF CSISVIFEIS HFGLINTSLS
VHSFTLPIFQ QQSRTQIFVF ITVLAFLLIY IMDEIHIIRQ ERTKYIKNVS NLINFGLKSV
FVFFVFLQVI KFKMGADIVK FYLLNPNDFI PFHTVSHVDQ TLRIIMGFLA FLIVLKTLRY
SRFFYDVRLA QRSILAALPG ICSMALVVAV YFFVYMAFGY LVFGQHEWNY NNMIHSAQTV
FSYCVSAFKD TAFTSNRLLG GLFLASFMLV MICVLINLFQ AVIMSAYEDM KQPVYEEPSD
EAEVITFLVH KIRRIWYFIT CRTPAASDPD LFNSVLYGQA QRYSHRHLGL KTKKINGKKM
VYLVI
//
