ID A0A452IDI2_9SAUR Unreviewed; 741 AA.
AC A0A452IDI2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000025912.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000025912.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
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DR AlphaFoldDB; A0A452IDI2; -.
DR STRING; 38772.ENSGAGP00000025912; -.
DR Ensembl; ENSGAGT00000029476.1; ENSGAGP00000025912.1; ENSGAGG00000018917.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd09540; SAM_EPS8-like; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF19; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 516..575
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..50
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 741 AA; 81485 MW; C08B8D9F5BD56423 CRC64;
MGASAPQRGQ APGPIPSPPE PASPCPGAGW EPAPPRGDRP RAPFPAPLSQ PVPALGLDGS
QRPPRGDRPL PHSPFIICPS LYTEQRKKYS NFIMADVSQY TVNHLVTFPV GEAAELHSVE
DAVRKVAAMD AQGQLWAQEM LLQVTGSAIR LLDVHSKEEL ESYGLAGVLR CEAVLPSARA
HSLLLLVCQE PQQTQPDAHF FQCTHIGAEP IREDINSALL GFTSGSNAQR KEALRWEAVR
GGEIRRVRDE ARLGLHVHPI PWWRGGDDLL QSPPAPSWQG FGGWGSGGCT EGPGPPAHPQ
ASAYHLPPPQ ELLNRIFDDI EAFVGKLQKS AEAFRVLKQL KRPNRGRRRE PGEGLLTLRA
RPPLMEEFQD TLAKLKYSFS LLARLQSNIL NPTSEELVHF LFGPLKMVVE SSGGPEFASE
IRSPMLTLEA VTLLRGCLGA QEAELWGSLG DDWTRPRVEF PGDYAAPYTL SFQSGWAPPR
LGPDGQPWED PVETQHRHEL RRAQVTGVGK SHGRTEESRL VSCTYDFVAR NSNELSVLQG
EVLEVLDNTK KWWKVQNRSG QQGYVPFNIL SPLPATQNRG PGDPLNGTGS ADCSPRQTRA
PVSPAIWERL SRPAERLNEE LLQRLAAGRG TPAKPFRVHR APDTSVPLDH DSDPAQVQAW
LEAKGFEPLT VSTLGVLNGS QLFSLSKAEF QAVSPEEGAR VYSQVTVHKA MLEDFRKTSE
LEAVMEKRKR KLEGKTEASR S
//
