ID A0A452IIU8_9SAUR Unreviewed; 1944 AA.
AC A0A452IIU8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000027714.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000027714.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR Ensembl; ENSGAGT00000031484.1; ENSGAGP00000027714.1; ENSGAGG00000008473.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF278; SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 347..374
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 714..735
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 770..794
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 832..852
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 911..937
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1153..1171
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1192..1214
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1220..1240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1269..1295
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1394..1417
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1475..1493
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1505..1523
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1530..1554
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1592..1620
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1696..1719
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 143..380
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 505..663
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 713..944
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 951..1147
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1151..1426
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1474..1729
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 35..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1897..1944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 371..416
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 35..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1900..1916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1917..1944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1944 AA; 222129 MW; 054A43A1C1206308 CRC64;
MAQALLEPPG PNSFFYFTRE SLAAIEQRVT EEKANCLKED HKDDDVNDKN GPKPNSDLEA
GKTLPFIYGD IPPGMVSEPL EDLDPYYINK KTFIVLNRGK AIFRFNATPA LYILSPFHPL
RKAAIKILVH SYPFHVVCLE LVYWAKNVEY TFTGIYTFES LIKILARGFC IGHFTFLRDP
WNWLDFTVIA FAYLTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA LIQSVKKLSD
VMILTVFCLS VFALIGLQLF MGNLRHKCLL WPLNVSSSEN RFASFFINDT VQCPEGYTCI
KAGRNPNYGY TSFDTFSWAF LSLFRLMTQD YWENLYQLTL RAAGKTYMIF FLLVIFLGSF
YLINLILAVV AMAYEEQNQA TLEEAKQKEA EFQQMLEQLK KQQEEAQAIA EAAAEFRDFG
GKDRICGLSE SSSEASKLSS KSAKERRNRR KKRRQRELSG GEDKLDDEKF PKSDSEGNIR
RKGFRFSLEG NRLTYEKRFT SPHQSLLSVR DSLFSPRRNS RTSLFSFRGR VKDVGSENDF
ADDEHSTFEE DSRRGSLFVP LRHERHNSNI SQGSRSSRRL PVNGKMHSSV DCNGVVSLVG
GQTSLLSPTG QLLPEVIIDK PTTDDNSTTS EIEIKKRRSS SYKISMDLLE DPTIRHRAMS
IASILTNTME ELEESRQKCP PCWYKFANTF LIWDCWAPWL KVKHIVSLIV MDPFVDLAIT
ICIVLNTLFM AMEYYPMTEH FHNVLSVGNQ VFTGIFTAEM VLKLIAMDPY YYFQVGWNIF
DAFIVSLSLL ELFLSKVDGL SVLRSFRLLR IFKLAKSWPT LNKLIKIIGN SVGALGNLTL
VLAIIVFIFA VVGMQLFGKS YKDCVCKISK ECVLPRWHMQ DFFHSFLIVF RVLCGEWIET
MWDCMEVASQ AMCLIVFMMV MVIGNLVVLN LFLALLLSSF SSDNLAAIDD DNETNNLQIA
VARIQRGIDY VKRKACECIQ KTFVRGQKDI DEVRSTSQLN NKEDNYTANH TVAEMNKHLN
NRKDNNGTTG VVGNHDYASF IHNPSLTVTV PIAIGESDFE PLNTEEFSSE SELEESKEKL
NIYSSSEGST IDINYLGEEK ANFESEDALE PKACFTEGCV RKFKFCQVSL ENKKGKIWWN
LRKTCYKIVE HNWFETFIVF MILLSSGALA FEDIYIDKHK TIKIMLEYAD KVFTYIFILE
MVLKWVAYGF QTYFTNAWCW LDFLIVDVSL ISLTANALGY SELGPIKSLR TLRALRPLRA
LSRFEGMRVV VNALLGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFFSC VNTTSGNPFP
REKIENKTDC ENFMKSHEDV LWKNVKVNFD NVGAGYLSLL QVATFKGWMD IMYAAVDSTD
VSQQPKYEES LYMYFYFVIF IIFGAFFTLN LFIGVIIDNF NQQKKKISQD IFMTEEQKKY
YNAMKKLGSK KPQKPIPRPA NKFQGLMFDI VTKQAFDISI MILICLNMVT MMVETDDQSD
EMKHILYWIN MVFIVLFTGE CVLKLISLRY YYFTIGWNIF DFVVVILSIV GMFLDKVIEK
YFVSPTLFRV VRLARIGRIL RLIKGAKGIR TLLFALMMSL PALFNIGLLL FLVMFIYAIF
GMSKFAYVKK ESGIDDMFNF ETFGNSMICL FQITTSAGWD GLLAPILNSG EPDCDPNKPH
PGSSVKGDCG NPPVGIFFFV SYIIISFLVV VNMYIAVILE NFSVATEESA EPLSEDDFEM
FYEVWEKYDP DATQFIEYSK LSDFAASLDP PLLIAKPNTL QLIAMDLPMV SGDRIHCLDI
LFAFTKRVLG ESDEMDALRI QMEDRFMAAN PSKVSYEPIT TTLKRKQEEV SATVIQRAYR
HYLLKKTVKK VSFMYHKGKH GLPIKVDMTL DKLSENSAAE KTDKTLSTTS PPSYDSITKP
DKDKYEKDNS EKEDKSKDTR ESKK
//
