ID A0A452ILZ8_9SAUR Unreviewed; 3763 AA.
AC A0A452ILZ8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Ryanodine receptor 1 {ECO:0000256|ARBA:ARBA00014291};
DE AltName: Full=Skeletal muscle calcium release channel {ECO:0000256|ARBA:ARBA00032969};
DE AltName: Full=Skeletal muscle ryanodine receptor {ECO:0000256|ARBA:ARBA00031197};
DE AltName: Full=Skeletal muscle-type ryanodine receptor {ECO:0000256|ARBA:ARBA00033030};
DE AltName: Full=Type 1 ryanodine receptor {ECO:0000256|ARBA:ARBA00032832};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000028934.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000028934.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR STRING; 38772.ENSGAGP00000028934; -.
DR Ensembl; ENSGAGT00000032867.1; ENSGAGP00000028934.1; ENSGAGG00000015224.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.490.160; -; 3.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 217..427
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 643..839
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 978..1191
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 967..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1482..1511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3008..3027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3550..3650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3729..3748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..983
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3013..3027
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3763 AA; 423088 MW; 1689AEC94BB712E4 CRC64;
MALPAPQAIL HQEGHMDDAL SLTRCQHEES QAARIIYSTS GLYSHFVRGL DSLSGKGKAG
AGTALPIDGM ILSLRDLIIY FQHPEEELRH EEKQGRLRSL KSRQNLFQEE GMITLVLDCI
DRLNLYSTAA HFAEFAGEEA AESWKEIVNL LYELLASLIR GNRSNCALFS SNLDWLVSKL
DRLEASSGIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD KHGRNHKVLD VLCSLCVCNG
VAVRSNQNLI TENLLPRRDL LLQTSLINYV TSMRPNIFLG THEGSTQYKK WYYELIVDYV
EPFVTAQATH LRVGWAIAEG YSPYPGGGEG WGGNGVGDDL YSFGFDGLHL WSGRVARAVA
SPGQHTLAAD DVVSCCLDLS VPSMSFRING FPVQGMFENF NVDGLFFPVV SFSAGIKVRF
LLGGRHGDFK FLPPPGYAPC FEALLPRERM RVEPIKEYRQ DVGSVRSLLG PTQALSHTAF
TPCPVDTQQI VLPPHLERIR EKLAENIHEL WALTRIEQGW TYGPIRDDNK RLHPCLLDFH
SLPEPERNYN LQMSGETLKT LLALGCHVGM ADEKAEENLK KTKLPKTYMM SNGYKPAPLD
LAHVKLTPAQ NTLVDKLAEN GHNVWARDRV SQGWTYSIVQ DIKNKRNPRL VPYNLLDERT
KKTNRNSLCE AVRTLIGYGY NIEPPDQETS AQGIPTARSE RVRVFRAEQC YAVRAGRWYF
EFEAVTTGEM RVGWARPDVR PDVELGADEL AYVFNGHRGQ RWHIGSEPFG RSWQPGDVVG
CMIDLTENHI MFTLNGEMLI SDSGSELAFK DIEIGEGFLP VCSLGLGQVG RLNLGQEVSS
LRYFPICGLQ EGFEPFAINM KRDISMWFSK SLPQFSPIPP EHPHYEVLRI DGTVDNPPCL
KLTHRTFGSQ NAVSELLFLR LSMPVEFHEK FKCTAGATPL TRALTIPEED VKDVDLDSEF
EVLRKSAGRK EAEEAEKEKQ AGALASPKEP PRAENEKDAA SEKSKIKRGF LFKAKKATFI
TPPPVVPSVQ RLEEDVVPDD RDDPEIIMNT TTYYHSVRIF AGQEPTCVWV GWVTPDYHQH
DMAFDLSKVR TVTVTMGDDQ GHIHDSIKRS NCYLVWGGEF VSSGQQTRVS TVDLVLGCLV
DLATGLMTFT ANGKEINTFY QVEPNTKLFP AVFVLPTSQN VVQFELGKMK NIMPLSAAMF
HSERKNPEPQ CPPRLVIQML TPVTWSRVPN EFLTVERARI SDRHGWMVEC GDPLVMMALH
IPEESRCIDI LELSEHLALL TFQHHSLQLY CAVCALGNNR VAHALCSHVD ESQLLYAIES
PHLPGPLRSG YYDLLMSMHL ESAKRARLTM NSEFIVPMTD ATKSIRLFPE GSRKPGLPGV
GTSTCLRPPL HFAPPCFVST SPERYQLSPE LPLEALKLKA LAMLTEAVQD GGQHSRDPVG
GSVQFHFVPI LKLVSTLLIM GVFGDEDVRH ILRMIEPAVF GEPAEEERGE AEKPEEEEGE
KARAKAGEEE AEGLEEGLLQ MKLPESVKLQ MCNLLQYFCD RELQHRVEAI IAFSERYVDR
LQSNQRQRYG LLMQAVTMSA AETARRTREF RSPPQEQINM LLHFKHGADE EECPVPEDIR
DELLDFHTDL LSHCGIEAEG GEEEEEEDTS LQHRLRTLVE KVLSFRKKKE QEEELPPEEE
PAPSTLQELI SHTMVHWAQE SFIQSPALVR VMFSLLHRQY DAIGELLRAL PRAYTINAVS
VGDAISLLES LGQIRSLLIV QMGPEEETLM IQSIGNIMNN KVFYQHPNLM RALGMHETVM
EVMVNVLGGG ESKEIRFPKM VTNCCRFLCY FCRISRQNQR SMFDHLSYLL ENSGIGLGMR
GSTPLDVAAA SVIDNNELAL ALQEQDLEKV GGGAGGCGAK TPPRLARCPP APAGESVEEN
ANVVVRLLIR RPECFGPALR GEGGSGLLAA IEEAIKISED PARDGPTVKK DRRRELFGGE
ETHEENRVHL GNAIMSFYAA LIDLLGRCAP EMHLIQAGKG EALRIRAILR SLVPLDDLVG
IISLPLRCLP PDGNVVEPRM SASFVPDHKA PIVLFLDRVY GIESQDFLLH VLEVGFLPDM
RAAASLDTAA FSTTEMALAL NRYLCCAVLP LVTKCAPLFA GTEHRAIMVD SMLHTIYRLS
RGRSLTKAQR DVIEECLMAL CRYIRPSMLQ HLLRRLVFDV PILNEFAKMP LKLLNNHYER
CWKYYCLPTG WASYGVSSEE ELHLTRKLFW GIFDSLAHKK FKAELYKLAM PCLCAIAGAL
PPDYVDASYS SKMEKKASVD AEGNFDPKPV ETLNVIIPEK LDAFINKYAE HTHEKWAFDK
IQNNWTFGET IDEEAKTHPM LRPYKTFSEK DKEIYRWPIK ESLKAMIAWE WTVEKPHEGE
EEKTEKKKTR KISQSHFLAG WAMAEQLAEN YHNTWGRKKK QELEAKGGGS HPLLVPYDTL
TAKEKARDRE KAQELLKFLQ MNGYAVTRGL KDMELDSSSI EKRFAYGFLQ QLLKWMDISQ
EFIAHLEAVV SSGRVEKSPH EQEIKFFAKI LLPLINQYFH NHCLYFLSTP AKVLGSGGHA
SNKEKEMITS LFCKLAALVR HRVSLFGTPR LSHSLGRTVM KSGPEIVKAG LRSFFESASE
DIEKMVENLK LGKVSQSRTQ VKGVAQNINY TTVVLLPVLT SLFEHIAQHQ FGDDVILDDV
QVSCYRTLCS IYSLGTTRNP YVERQRPALG ECLARLAAAM PVAFLEPHLN MHNPCSVYTT
KSPRERAILG LPSCVEEMCP DIPELERLMK EISGLAESGA RYTEMPHVIE VTLPMLCNYL
LRWWERGPET LPQGPWCTQV TSEHLNTLLG NILRIIVNNL GIDEASWMKR LAVFAQPIVS
KARPELLRSH FIPTMEKLKN RSGKVVAEEE QLRLEAKTES EDTELLIRDE FSVLCRDLYA
LYPLLIRYVD NNRAKWLMEP NSDAEELFRM VGEVFIYWSK SHNFKREEQN FVVQNEINNM
SFLTADSKSK MSKAGSSEQE RTKKKRRGDR YSVQTSLIVA TLKKMLPIGL NMCSPTDQEL
ITLAKGRYAL SPLFLSGCEN PASMRWQMAL YREMSGKAED ANRPEKIVRR VQEVSAVLFH
LEQTEHPYKS KKAVWHKLLS KQRRRAVVAC FRMTPLYNVP RHRACNMFLE SYKLAWIITE
EHAFEDRMID DLAKPGEEEE EEEEQMEKNP DPLHQLILHF SRTALTEKRW VLGAGAASTS
SHPTWGVNPP ACADPCVSTP QEKEMEKQKL LYQQSRLHNR GAAEMVLQMI SACKGSIHTP
PSLALLTPIS PCSVLDLNAF ERQNKAEGLG MVTEEGTIIR RENGEKVMAD DEFTQDLFRF
LQLLCEGHNN DFQNYLRTQT GNTTTVNIII CTVDYLLRLQ ESISDFYWYY SGKDVIDEQG
KRNFSKAMAV AKQVFNSLTE YIQGPCTGNQ QSLAHSRLWD AVVGFLHVFA HMMMKLAQVT
QLPARVGGAC RGTSVSPAKG LPSSSGXRGY EFGTFHKWGD EIGTFHTETA RTFPVGADPF
PASNVNFWKP PAGVTSGEGE EPCETSALGL PFCGRKPDAP PPSPPSSSSG GGRSLRVVTS
ALGPDRGGPR LLCPHREEEA GGGECGGVSV RPAVTIPPPN RGEXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXPP PPHPIPTYQF RLRFSHRPRD QLQ
//
