ID A0A452IP25_9SAUR Unreviewed; 6200 AA.
AC A0A452IP25;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000029599.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000029599.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSGAGT00000033611.1; ENSGAGP00000029599.1; ENSGAGG00000021364.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.2030; -; 34.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR026919; ADGRV1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009039; EAR.
DR InterPro; IPR005492; EPTP.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR46682; ADHESION G-PROTEIN COUPLED RECEPTOR V1; 1.
DR PANTHER; PTHR46682:SF1; ADHESION G-PROTEIN COUPLED RECEPTOR V1; 1.
DR Pfam; PF03160; Calx-beta; 33.
DR Pfam; PF03736; EPTP; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SMART; SM00237; Calx_beta; 18.
DR SUPFAM; SSF75011; 3-carboxy-cis,cis-mucoante lactonizing enzyme; 1.
DR SUPFAM; SSF141072; CalX-like; 37.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50912; EAR; 5.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5841..5861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5905..5930
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5951..5977
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5997..6018
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 6025..6049
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5885..6050
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 6200 AA; 680887 MW; 3A4FE43E8916F137 CRC64;
MHNVRVTVSA RAAGGVHRTR MSMSSGLGMP SACLLVNFLL GLFISFTSGE TEVKFTGQTE
FVVLETSTTV IRLVVERTGE PANITAIVSI YGENTGDFFD TYAATYIPDT ETNRTVYISV
CDDDLPEADE MFTFYLTLQK PSAGIKLGSP RSVTVTVLSN DNAFGIISFN MSALITVNEP
RGRNEFVPLT LIREKGTYGT VTVTFEVEGG PNPAEEDLSP AKGNITFPPG RAVLFYNLTV
LDDQIPENDE IFNVHLRSVE GGAEINTTRN TVQITIKKND SPVRFSQSAY MVPEEVDVLT
IQVVRGKDDS GKLIGSDEYE VSVCYIIITG NSTAHAQLNL DFLDLQPNVT IVFPSQVHES
DMKFKIFDDA IPEIAETFQI MLLKDTLQGD AVLISPSIVH VTIKPNDKPY GVLSINSVLF
AQVVIIDEDQ TSRFEGITVA RNGGTHGNVS VTWIITRNSS DPSPVTADIT PASGVLHFAQ
GQMLASLPLN IISDDIPEEA EPYLLRILAD TIQGGAEVSE PAELLFYIQD SDDIYGLMEF
YPLKNQRIES NLTGRFLSLS FARQRGTVGV IRLVYIVLYV PAGTVDLERS KDGILNVSGR
GILIFPEGKC QDILNLPIRN DAFLQNGAHF LIQMERVELV NIIPPIPPIS PRLGEIRNIS
LRITPDIANG EIGFTSNLPI ILHEPEDSSA TMVSIALHRD GTDGQATVFW SLKPSGLNPK
AVTYDDLSPF NGSVLFLSGQ SDTTINITVK ADDIPEMNET VTLTLDRVSV ENEILKSGFT
SCELIVVEND DPGGVFEFSS SSRGPYTIKE GESVELQIVR SKGTLVKQFL RYTVEPRDSN
EFYGNTGILE FKPGEREIVI TLLTRMDGVP ELDEFYSVVL SSHSELTSKL GTATRVNITI
LKNDDPHGVI QFLPDELAVT INESKGEAVY AAAYRIVRNQ GNYGNVSVSW VVEPVSTNDI
YPVQGTVFFG NQEFSKTITI YSLPDELPEE MEVFTISLVN TTGGARVGNT TSAVLQITRN
DDPIYFSDPV VKVQEGDFAH ITVLRNGSAD VAITVLYATV DGRATVEDGD FISSGRSKAL
VFDVGEREHK ILVFISEDDT PETDETFYII LFNSTGDTVV YRTGMATIVI EANDDPNGIF
SLEPIDKPVE EGKTNVFLIL RQRGHFGNVS LTWQLFENDS ALEPGQEFYE IYGTVWFMDG
EGSKAVTLHA IPDKIPEFNE FYTLKLLNAS GGSPGPGGQL AETNLAVIVM IPFNDDPFGV
FVIDPESQDR EIVEDVLSED DLSYITNFTI WRQQGTFGDV RVGWEILSSV FPAGLPPMID
FLLLGSFSNS VRSQPHRRRH HSETDALYFS GKEDAFGTVD PDFHFSWDNL LFNFTFSAWV
IPNLNSDGFI VAKDNYNGTM YYGVKIQTNE SHVSVMLHYT TLVSNITYVA KTTIMKHVKE
NTWLHLLITL EDGIIEFYID GNPVPGGMKS LKGAAIADGP GIVRVGAGVN GSSRYTGLMQ
DVRLYERKLT RTEIDELHAT PARTDVHPIS GYLEYRQGET KKSFIVSARD DEEEEGEELF
ILKLVSVHGG ARIPEENTIA RLRVQKSDNA NGLFGFTGAC IPETSDEGST ISCVVERTRG
ALDYVYIFYV ISQIDSTSIN YSVADFANTS GTITFLPWQR SEVLNLHVLD DDIPELNEYF
RVTLVSAVSG DGKLGSTPTS GASIDPEQET TDISIKASDH PYGLLQFSMG LLPGPSDKMI
LPATMVPRIT VKEEIGHIRL LVVRAQGLLG TVMVEYKTVS LTAFSPEDYQ SIAGTLEFQP
GERYKYITVN ITDNPVPELE KAFQVELLNP EGGVAELFRN DGSGSGDGDL EFFLPAVHQH
ASLGIASHII VTIDASDDAH GVFEFSAESL SVNGTEPEDG DSVIVLQVVR NQGALSHVTL
HWIIVCDPTE DLISTYGNIT FDVGQRRANI TVQVSPDEYP ELDKMFSILI INVSSGRLGI
HTNATLTVLA NDDPYGIFIF SEKNRPIKVE EETKNITLTI VRLYGLLGTV IVTYRTMDDD
EKSPYLKSNV ARATQERDYI PISGFVIFRA NTSEASITLP ILDDKDPERS ESVFVELLNI
ALVERVQDRS IVNSPRLGPK GDTVAHVIIN ASDDAFGTLQ LSAPAVRVAE NYIGPIINVT
RTGGIFADVS VKFKAVPITA RAGEDYSVAS SDVVLLEGET SKAVPIYIIN DINPEVEETF
HVQLLNQTTG GALLGALTQS VISIEASDDP FGSFVFQVNE LTVEEPEFNS KMVNLPIIRN
AGTLGNVTIQ WIATINGQLA TGDLRVVSGN VTFAHGEAIQ TLLLEILADD DPEIQEVIHV
QLTQASNGGA IGFDGMTNII IPANDNPYGT VCFHHALYRI QEPLERSSFA NITVKRSGGR
FGQLQVFYST SEVDVVALAI EQGQDILSYY EFPVQGIPNQ LSRTKVNVST ASDPLHTCAI
QCLKEQACLA FTFSSASGFP LCFWLTTWIS PVTNNSGFWT YKKNVTSVSS LFGAQAIAGS
DYESVTSQWA IMLEGEQFAN LTVTILPDNL PELDEKFAVS LLKVELMNTS ASLKNHPMIG
KTNTSIVIIM MNGDAFGVFV IYSVSPNTTE KGLYVEVEER PYTNVQLMIH RTEGSLGQVT
VEWNVIGGTA TQNLDFVGDG EILVFAEGET KKMVTLTILD DSEPENNENI IISLTHTEGG
SRILPSSDTI TVVILANDNV AGVISFQTAS RSVIGHEGEQ LQFHVLRTAP GLGNVTVNWK
IVGRRLDQTF ENYSGVLFFP EESLNLTFCV HLLDDHIPEE KEEYQVVLYD IRTQGFSSVG
AAVLDSQRYE AVLTIEASDE PHGVLNFASS SRMVLIQEAN KTIQLFISRE FGSLGVINVT
YATVPGLLRV RNQTEGTLAE PGVDYIPVSG WLLLGEGETS ASINVTILED DIPEVQEFFL
VNLTSVELTM NPLMSFPPRL DAEGLGAQII IDANDGVRGV IEWQNTNFEI DEIHGSLTLV
AYRNRGSSGN VSLFFYAQNL EAKLGLDFNV TSRILSFADG ERYKHIDVMI FDDDIPEGDE
KFQLILTNPS LGLELGENTT ATVTILASDD GHGVLSFNNS DHFFLREQSA LHLMESVAVL
NIIREPPQGI FGTVTVQYLV REINSSAASV DLTPSQGYIM LEEGVRFKTL HISAILDEEP
EMDEHFIVTL FRPMGGARLG TRVETMVTVL QNQAPLGLFS VYPVTNRTSS LITEEANSSV
YLKVSRSNGL NMSVSVEWET LSNTAFGLKG GISVLSVLQS FVEESVSSWC FFTSGESLYG
VLLRTSPASF SSIYQWRGVF VPIEDFSIRN PQSCVTFHIN GAAFLVITHG GTKQDSSNNH
VYTFTPGLRV LLIQTLSVPE TRDVKHFIVN SKDYLIIASH TTDSRSIQVF QWNDGLFVLH
HQLPIYGALH MALFPRGGFM YLAVSLSNSS QHPLLYQWSE DEFQKLHQVP VNGITHMEAL
TSGSDIYLIV AKESSNSSEV FVWETGQSSF RHFQSLSSSV INKIHTFMPP SGLVHVLLAG
KDRSALYSWN SEVNQFSLVL EAPPANHITS VTKRSLNSNK SLIVLSGDSY SQIYELTKVS
NESDFIPSSG ELIFEPGDME VVLAVNILDD IIPEEEEFFT VWLKNPKGGA EIGASGYVNI
IIPSNDNAHG VIAFAQNSLS KQVEEMEQDN LITLNIERLI GTYGRVTVQW MANGSINDIF
PASGMIIFSE GQALSTITLT VLADNIAELS ETVVITLTNV ITVSIKDPMR GAIIDPKRAR
AVLTILPNDS PYGVVGWHTE SLFAKVAEPE ENPTIVTLQI LREQGFVGDI AVQLSTKPDF
ALQPFNQATE NQDYVIEKET IIMAENTVMT YVIVTILPDH VPELQEGFVI NITDVHLLDS
SLAGGQPSVK RLGLEIAEII IEENDDPRGI FSFNVLKDFS GAVAGYEVPP PQNILKLPVV
RKAGRFGSVK LYWEAMPASA SVEDFTPSFG NLTFADGQAA GVIEITIIDD TAVEFLELFN
VTLIRVTGGA RLGDDTVVTV TIPPNDSPVG VFGFEEKNVT IKEPQSPGDS AATVLLTVSR
SQGGWGAVRI IWILEEAARY DLTPLNGTLY FNETESQKTV VLRAIQDGLL EGNEMHTIQL
VSTDNAEVSP INGLATIIIL GDHGASGVVG IAPSSNHILI GEPSGKYNGT AFISLVRGPG
IFGEVTVYWN ITPPLKKEFA EISGTLIMRD RQSAAGVLIQ AIDDNLPEEK SYYQFHLSGV
SDGGVINEST SIANITMVAS DFPYGQFAFS QENLQITEEE KWVNITIARS SGYYGRVQLW
YWTLNGTAEE SIDFTSSSGE LVFEPNETTK GISVEIHDDD LPEGPEEFSV TITKVELQGS
GFDFAVRENG LQVDQPPGIG NISKVHIIIM KNDNAEGIIE FDPWYITLQV EEDVGMIMIP
VVRKRGTHGY VTADFLSRSI SALPNSIDYS VSNNSVIFHH GQNRSFISVS ITDDDEREFA
ERFEIQLIGA TGGAVLGLHL VSQITIAKSD SPNGLVRFLN QSQIILPNPS SSLTLSLVLE
RTGGLIGETQ VNWDILGPNS EEVLSPLNSD IGDPVNGSFY FREGEGGLRA ISLKIYPHGE
VEVQEIFIIR LSLVKGETEV DPKSTNVTLI IQKFGDPNGI VQFAPESLSS KNYEEPSVLE
GPENITLFIK RVQGTLGNIT VHWKLSGDSD TTGDFLATKG TVSIAENQST AEIIIHLLPD
DVPEVDENYV VELLSVEGGA DLDQDKRVLR FTVLANDEPH GVFALYSDRQ SVLVERDLSR
HIQMNITRHA GTLGDVSVEY RISPRHREPL ITPENTVGCL LVKDGASFGV KRVPISSQVF
LLLGLNFTLE LTNASLINGR ANYMPKIILG RAKSATLSVP EEAANSQVGF ESLILQLTNI
IEGTGKAVIT RKGVYGSVTV SWTSGYPLDL IPEFVQPGNI TPGFGNVTFS YGEKNKVISF
HVIPSLSRPE AFAIHLTSVY SNVSGGAQLR SGFTVAEIEP MGVFQFSPNS RHVSVEEDVQ
VIRLHVQRLF GFQSNLTKLA YQTIAGSAKP LEDFGPVQNG ELVFGHFQAE DIVEISIIDD
TISEMDEVFF VKLTSVEVLA IEKFNPNRNP RLNPDFSVAA ITVLANDIVH GIMSLGPGFI
YTEEDTNNST PNTVILNIRR TQGFAGDVKV TVKTFGGVSA QSGVDEFPFE NVYGNSNLTW
ATEGMDFEEK IISVTLLDRE KESKVSIRIL DDDEPEGQEF FYIFLSDPQG GAQIVEGKDE
YGFAAFATII ITGNDLQNGI LGFSAEVQSG LVLDEDSENR EVQLIVTRQP NRAFEDVKIF
WRVTFNKTSV VLGKDGVNLA NELLAVSGIT TCMAGQTICN ISVEIKPDRV PEFETYFFVE
LYEVSSGAAL NSSARFAYIT VPESDAAHGL VYFAVGSRLA VANKKTTLIS LQVVRDSSTA
LTISVNYNMQ ELKRPEAVGR TFISPAISGQ DFARSEGILT FEPGQRNAVL DVMLTPETGS
LNPFPKRFQV VLSNPTGGAR VDDAYDIANI TIVSDSDAQS VWGLADQLYQ PLDDIILNRV
LQNLNVKIST ETTEEQLTAV MHIIDKVMAE GEKQMLTDKS RNLFYEILCA LASPKRKDTR
GYSLLAEVTE KFAFSLLTGV ICGSPGEKGK TILDSCPYIA IMAHHWYPQQ INGHKFDGKD
GDSIRFPERL LEVSFASSPP RDENCKYVQF TEYSSQQWFI TGDKRTALKN KIFSMSLKGQ
SSYPLKDNNE VIYRIYSADS RIVPRKSLCL LWNQAAESWL SDSQFCKVVD DTSDYVQCSC
SHMSIYAVYA QTDNLSSYNE AFFSSGFICI SGFTLAILSH LFCARCSMFA AKLLTHMMVA
CLGSQAINFW YVLVMNDEHT QRRYLLFFLL SWGLPAFVVI LLLIILRGVY HQSMAQIYGL
VYGDLCFIPD VYAALFTAVL IPLMCLVVVF VVFIHAYQVT PQWKAYDDIF RGRTNAAEIP
LVLYLFALIS ITWLWGGLHM AYRHLWMLVF FVIFNSLQGL YVFVVYFILH NQLCCPVKAS
YTIDMNGHTS PGSAFFTHGS GMPPAGGEIS KSTQNLISAM EEVPADWERA SLRPASQASA
SFKQSPQNGN AFNASGGFSN GSLVADEESQ EFDDLIFALK TGAGLNISDN DSYHGSQDGG
SMANSQIVEL RRIPIADTHL
//
