ID   A0A452IQD8_9SAUR        Unreviewed;       943 AA.
AC   A0A452IQD8;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
OS   Gopherus agassizii (Agassiz's desert tortoise).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Testudinidae; Gopherus.
OX   NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000030177.1, ECO:0000313|Proteomes:UP000291020};
RN   [1] {ECO:0000313|Proteomes:UP000291020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28562605;
RA   Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA   Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT   "The Agassiz's desert tortoise genome provides a resource for the
RT   conservation of a threatened species.";
RL   PLoS ONE 12:e0177708-e0177708(2017).
RN   [2] {ECO:0000313|Ensembl:ENSGAGP00000030177.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   AlphaFoldDB; A0A452IQD8; -.
DR   Ensembl; ENSGAGT00000034257.1; ENSGAGP00000030177.1; ENSGAGG00000021773.1.
DR   Proteomes; UP000291020; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   CDD; cd22095; F-box_FBXO18; 1.
DR   CDD; cd18786; SF1_C; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT   DOMAIN          99..148
FT                   /note="F-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50181"
SQ   SEQUENCE   943 AA;  106342 MW;  CD66CECCA65B9397 CRC64;
     MDEGLEDHCA LLGCDGDAKT APWGPVASRK RPLCSEGAGS NYTEYSKCGG TDKKPMIDSS
     LKYSPGHTEI RQDPDVIEID PIPDSYFGLL GTSCGKEPQG HIDQLPNEVL SIIFAFLPVT
     DLCLNLNLVC HRWREIISDP LFILWKKLYR QYLMKEAQAL LTVEWILDHY GITQEQDQCM
     LGFIRYMATS NAARRMDPDA VLRCLKKHHL FTKAEICIIQ RLPDLEGTAG AVNVWAVIAA
     IVLFSDGVHD IQKLMACLRK PGSTLSLLDI TEMLYCMATL LNAMREKGIN ISNRFHYSIF
     YSLYLMENAC PVTKTTMLET PSSNCGRGAW PSNKLDIKLT HEQQRILNHT ILPGQVVKIM
     AFAGTGKTST LVKYAEKFPH LSFLYVAFNK AIVENGKSVF PPNVMCKTFH SLAYTSVGKH
     YNEKGKLNFS NLSPYTISFI LKHRMGQSLF IRAKTVTQTL ESFFASSDEF ISVEHTPIWC
     KNTHGMRVLV SEEEKQIIVE EARRIWDNMK MLNGNTELNC RMTSDGYLKL WQLRKPRLFA
     YDAIFVDEAQ DCTPAIMDIV LSQSCGIIFV GDPHQQIYTF RGAVNALFAV PHTHIFYLTK
     SFRFGPEIAY VGSTILDVCK KIRNKMLVGG NQEGDVRGSM NGKTAFLSRG NLNVFENAVT
     ITGGERPTKI HLLGGPKNFG LDKIHDIWKL LQPEEARVRL KLQIDDHFIK KWVEKDGFQG
     LKNYAAKTED RELEVKITIV EKYNVRIPEL VARIKNSHVS NIAFADYVIG TVYKAKGLEF
     DTVLIADDFM KVSCARHNLQ RLPRFIPDMS AEDEWNLLYV AVTRAKKHLL MTKSLEYLLT
     LAGEYFLRPE LTSEALKEGA IHCSVSQCHN AVPADSILTM KKVPLTYSNG SKDQGGYLCH
     ACVQQRLGPL TQLTISPELV QTMDVVDEVL EIPRHLAVLY GLF
//