ID A0A452ISC4_9SAUR Unreviewed; 1098 AA.
AC A0A452ISC4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGAGP00000030767.1};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000030767.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000030767.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A452ISC4; -.
DR STRING; 38772.ENSGAGP00000030767; -.
DR Ensembl; ENSGAGT00000034894.1; ENSGAGP00000030767.1; ENSGAGG00000021709.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF9; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 694..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 725..758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 800..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..885
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 956..985
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1006..1026
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 117..375
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 744..990
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 1098 AA; 127114 MW; 4D9F31709D0CF1D6 CRC64;
MLIPKIFLSP HRWLRNGTLE GSKILYSSIS RSTDVSYNDS DLVTFIQEHF KKRECVFFTR
DAKSTDNLCK CGYSKSQHIE GTQVNNTEKW SYRKHTQEFP TDAFGDIQFE NLGKRGKYIR
LSYDTDSEML YDLMTQHWHL KNPNLVISVT GGAKNFALKP RMRKIFSRLI YIAQSKGAWI
FTGGTHYGLM KYIGEVVRDN TISRSSEENV VAIGIAAWGM ISNRDSLIRS SDTEGYYSAH
YIMDDLKRDP LYCLDNNHTH LLLVDNGTHG HPAIEAKLRT QLEKYISERV IPDSNYGGKI
PIVCFTQGGG KETLKAINVS IKSKIPCIVV EGSGQIADVI ASLVEAEGTL ASSSVKERLL
RYLPHTVSRL TEEETESWIR WIKEILENPH LLTVIKIEEA GDEIVSNAIS FALYKAFGTN
EQDKDNWNGQ LQLLLEWNQL DLASDEIFTN DRRWESADLE DVMFIALIKD RPKFVRLFLE
NGLNLRKFLN KEVLTELFSN HFSSLVFKNL QIAKNSYNDA LLTFVWKMVE DFRRGIKKED
KNGKDETEIR LLDESSITRH PLQALFIWSV LQNKKELSKV IWEQTRGCTL AALGASKLLK
SLAKVKNDIN AAGESEELAN EYETRAVELF SECYSSDEEL AEQLLTYSCE AWGGSNCLEL
AVEAKDQQFI AQPGVQNFLS KQWYGEISRD TKNWKIILCL FLFPLIGCGF ISFRKKPVER
SKKLLLYYAS FFTSPFVVFS WNVIFYVVFL LLFAYVLLMD FQDEPTMLEL ILYVLVFILL
CDEVRQWYMN GNKYFSDLWN VMDTLGIFYF ITGIIFRLRS SNESSWYSGR VIFCLDYIIF
TLRLIHIFTV SRNLGPKIIM LQRMMIDVFF FLFLFGVWVV AFGVARQGIL RKNEYRWEWI
FRSVIYEPYL AMFGQYPDDI DGTTYNFDRC TFSGNESKPL CVELDANNHP RFPEWITIPL
VCIYMLSTNI LLVNLLVAMF GYTVGSVQEN NDQVWKFQRY FLVQEYGSRL TIPFPFVIFA
YIYMVMKKCF KCFCKKECKE PSICCSKYED NETLAWEAVM KENYLVKINS KANDSSEEYV
CLLKQLIHSA SSKILEIL
//
