ID A0A452IUG7_9SAUR Unreviewed; 1488 AA.
AC A0A452IUG7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000031531.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000031531.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR STRING; 38772.ENSGAGP00000031531; -.
DR Ensembl; ENSGAGT00000035758.1; ENSGAGP00000031531.1; ENSGAGG00000022647.1.
DR Ensembl; ENSGAGT00000035763.1; ENSGAGP00000031535.1; ENSGAGG00000022647.1.
DR Ensembl; ENSGAGT00000035776.1; ENSGAGP00000031545.1; ENSGAGG00000022647.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18017; DEXHc_RecQ3; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR CDD; cd06141; WRN_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029491; Helicase_HTH.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR PANTHER; PTHR13710:SF120; WERNER SYNDROME ATP-DEPENDENT HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF14493; HTH_40; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT DOMAIN 523..689
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 714..865
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1117..1196
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1405..1488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..489
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1488 AA; 166160 MW; 475A44003BFF44EC CRC64;
MISPHHKLPQ WMSAQSKDDV GDKKKSLVQR SVLENDLPIL EFHGSVVYSY DASDCSFLSE
DIRINISGGD VIGFDIEWPP SYTKGKVGKV ALIQICVSEK KCYLFHISSM SGFPKGLKRL
LEDEAVKKVG VGIEGDQWKL MSDFEVKLKS FVELADVANE KLKCKEMWSL NGLVKHLFNK
QLLKDKCVRC SNWEEFPLNE EQKLYAATDA YAGLLIYQKL ENMSNCGQRL CSIKNDGEML
ANEVKKQLSS LAEEMVELAN GLPSTFGQLK NMQRALEILS GVSESIGALR NMLLGEPNSQ
AELESSCVAA PMKSEVVSTV VEEEKAETAE FPTRLQDDLN DDIDDDMLLS VNERDLTGSE
MEFSKSEQKD GTADRGSKDN TERDCIMSLD ITEYELQMLE LKAKEEILNE AALPEEPYSR
ENEQNLGCVI ESDEELEMEM LKSIEDVDNS KVRQTDSISI ETKRIDGTEL HLAPDDDEDE
GIEEEEEESW DPLLPVPNEI EVTCLKTYFG HSSFKPVQWK VISSVLQDRR DNLVVMATGY
GKSLCFQFPP IYTGGTGIVI SPLISLMEDQ VLQLEMSGIA ACLLGSAQSR NVIGDIRAGH
YRVVYITPEF CSGNLSLLQE LDQTIGITLI AVDEAHCISE WGHDFRNSFR TLGSLKKMLP
SVPVVALTAT ASPSVREDIV HCLNLKNPQV TCTSFDRPNL YLEVGRKTGR IFQDLKQFLI
KKESFTYEFE GPTIVYCPSR KTTEQVAAEL MKLNLSCGTY HAGMGIKARK DVHHRFMRDE
IQCIVATVAF GMGINKADIR RVIHYGAPKE MESYYQEIGR AGRDGLPASC YVFWTAADMT
FNRYLLNEIS NEGFRLYKLK MAAKIEKYLN SNSCRRKIIL SHFEDKQLRK ASSGIMGTEK
CCDNCRSRTL RCTINSDSEE SLQDFGHQAF QLMSAVKALD EKFGTRVPVL FLRGSNSQRL
PDKYRTHALF GSGKDWPENW WKALGRQLII EGFLKEVSGQ SRFATLCELT KKGRDWLCKA
RNELCRTLLL QPSEELYLRK PHTQSNRHVT SVAGQRSPDT RLIKLTPEKQ TYLQEMFTYQ
GASKISARGS VSNESSDLVP SPIKLKSPEP AVSSREKELH TVLYGKLLAA RQKLASEKDI
PPAVLATNKI LVDMAKIRPT TVENVKRIDG VSEAKSAMLV PLLDDVKEFC HENNLETDTF
PTCGSREKQP AALQKRGGCS PLPQSQLITY MLFHEKNQSL KSISESRSLP LSVVGSHLSQ
AMKAGYPVDL ERAGLTPEVQ KVITDIIQNP PINSDVSRMT AIRALVPANI ELYLIRMAIA
LLEKGCGNGQ LGQACDSGKK SLSAECEGLP ASMGPAQKSK EGTSRMETEG NSVKPTTHTY
KFVSREGAKQ DHQHMDSLSW LVKSSKMDDK QPSNAERDVP SHQTSLRLAS WNQPPLDPVE
EELFSDSQSK TQPAKRKLPG WFGTSKGTDS SITTGKKSKV GAKKGLFG
//
