ID A0A452IVA4_9SAUR Unreviewed; 2815 AA.
AC A0A452IVA4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGAGP00000031969.1};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000031969.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000031969.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSGAGT00000036248.1; ENSGAGP00000031969.1; ENSGAGG00000022899.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT DOMAIN 1233..1428
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1557..1715
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2760..2815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2777..2804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2815 AA; 317417 MW; F2EE1FC4C9EA3F93 CRC64;
MAAHKPVEWV QAVVNRFDEQ LPIKAGQQNT HTKVSTEHNK ECLINISKYK FSLVISGLTN
ILKNVNNMRI FGEAAEKNLY LSQLIILDTL EKCLAGQPKD TMRLDETMLV KQLLPEICHF
IHTYREGNQH AAELRNSASG VLFSLSCNNF NAVFSRISTR LQELTVCSED NADVHDIELL
QYISVDCIKL KRILQETVFK FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQTPQT
DMADCAEKLF DLVDGFAEST KRKAAVWPLQ IILLVLCPEI IQDIAKDVVE ETKINKKLFL
DNLRKALASH SGSRQLTESA AIACVKLCKA STYINWEDNS VIFLLVQSMV DDLKTLLFNP
SKPFSRGNQN ADVDLMIDCL VSCFRINPQN NPYLKICLAQ NSPSTFHYVL VNSLQRIITN
SEVDWWPKID AVYCHSVELR SMFSETLQKA VQSCGAHPAI RMTPSLTFKE KMTSLKFKEK
PTDLETRSYK FLLLSMVKLL HADPKLLLYN PRKQGPETQS STAELITGLV QLVPQSNMPE
IAQEAMEALL VLHQLDSIDL WNPDAPIETF WEISSQMLFY ICKKLTGHQM LSSTEILKWL
REILICRNKF LLKNKQSDRS SCHFLFLYGV GCDVSGGGAS QLSLDHEEMR CAPGATLRKG
KGNSSMESTA GCSGTPICRQ AQTKLEVALY MFLWSPDIEA VLVAMSCFRH LCEEADIRCG
VDEVSVHNFL PNYNTFMEFA SVSNMMSTGR AALQKRVMAL LRRIEHPTAG NTEAWEDTHA
KWEQATKLIL NYPKTKMEDG QVTDSLHKTI VRRRMSHVSG GGSIDLSDTD SLQEWINMTG
FLCALGGVCL QHRSNAGLAT YSPPMGPINE RKGSMISMIS TEGNAETPVS KFIDRLLSLM
VCNHEKVGLQ IRTNIKDLVG LELSPALYPM LFNKLKNTIS KFFDSQGQVL LTETNTQFVE
QTIAIMKNLL DNHTDGSSEH LGQASIETMM LNLVRYVRVL GNLVHAIQIK TKLCQLVEVM
MERRDDLSFC QEMKFRNKMV EYLTDWVMGT SNQATDEDVK CLTRDLDQAS MEAVVSLLAG
LPLQPEEGDG VELMEAKSQL FLKYFTLFMN LLNDCSEVED ESAQTGGRKR GMSRRLASLR
HCTVLAMSNL LNANVDSGLM HSIGLGYHKD LQTRATFMEV LTKILQQGTE FDTLAETVLA
DRFERLVELV TMMGDQGELP IAMALANVVP CSQWDELARV LVTLFDSRHL LYQLLWNMFS
KEVELADSMQ TLFRGNSLAS KIMTFCFKVY GATYLQKLLE PLLRTVIMSS EWQHVSFEVD
PTRLEHTESL EANQRSLLQM TEKFFHAIIN SSSEFPPQLR SVCHCLYQVV SQRFPQNSIG
AVGSAMFLRF INPAIVSPYE AGILDKKPPP RIERGLKLMS KILQSIANHV LFTKEEHMRP
FNDFVKSNFD AARRFFLDIA SDCPASDTVN HSLSFISDGN VLALHRLLWN NQEKIGQYLS
SNRDHKAVGR RPFDKMATLL AYLGPPEHKP VADTHWSSLN LTSSKFEEFM TRHQVHEKEE
FKALKTLNIF YQAGTSKAGN PVFYYIARRF KTGQINGDLL IYHVLLTLKP YYAKPYEIVV
DLTHAGPSNR FKTDFLSKWF VVFPGFAYEN VSAVYIYNCN SWVREYTKYH ERLLTGLKGS
KRLIFIDSPG KLAEHIEHDQ QKLPAATLAL EEDLKVFHNA LKLAHKDTKV SIKVGSTAVQ
VTSADRTRVL GQTVFLNDIY YASEIEEICL VDENQFTLTI ANQGTPLTFM HQECEAIVQS
IIHIRTRWEL SQPDSIPQHT KIRPKDVPGT LLNIALLNLG SSDPSLRSAA YNLLCALTCT
FNLKIEGQLL ETSGLCIPAN NTLFIVSISK TLAANEPHLT LEFLEECISG FSKSSIELKH
LCLEYMTPWL SNLVRFCKHN DDAKRQRVTA ILDKLITMTI NEKQMYPSIQ AKIWGSLGQI
TDLLDVVLDS FIKTSATGGL GSIKAEVMAD TAVALASGNV KLVSSKVIGR MCKIIDKTCL
SPTPTLEQHL MWDDIAILAR YMLMLSFNNS LDVAAHLPYL FHVVTLLVAT GPLSLRASTH
GLVINIIHSL CTCSQLHFSE ETKQVLRLSL TEFSLPKFYL LFGISKVKSA AVIAFRSSYR
DRSFSPGSYE RETFALTSLE TVTEALLEIM EACMRDIPTC KWLDQWTDLA QKFAFQYNPS
LQPRALVVFG CISKRVSHGQ IKQIIRILSK GLESCLKGPD NYNSQVLIEA TVIALTKLQP
LLNKDSPMHK SLFWVAMAVL QLDEVNLYSA GTALLEQNLH TLDSLRVFND KSPEEVFMEI
RRPLEWHCKQ MDHFVGLNFN SNFNFALVGH LLKGYRHPSP TIVARTVRIL HTLLALVNKH
RNCDKFEVNT QSVAYLAALL TVSEEVRSRC SLKHRKSLLL TEVSMENVPM DTYPIRHSDT
SCRTLKENQP WSSPKGSDRH LAANYPTVGQ ISPRTRKSMS LDMGQPSQAN TKKLLGTRKS
FDHLISDTKA PKRQEMESGI TTPPKMRRVA ENDYDMETQR ISPQQHPHLR KVSVSESNVL
LDEEVLTDPK IQALLLTVLA TLVKYTTDEF DQRILYEYLA EASVVFPKVF PVVHNLLDSK
INTLLSLCQD PNLLNPIHGI VQSVVYHEES PPQYQTSYLQ SFGFNGLWRF AGPFSKQTQI
PDYAELIVKF LDALIDTYLP GIDEETSEES LLTPTSPYPP AVQSQLSITA NLNLSNSMTS
LATSQHSPGI DKENVELSPT TGHSNSGRTR HGSASQVQKQ RSAGSFKRHS SKKIV
//
