ID A0A452IVP3_9SAUR Unreviewed; 2457 AA.
AC A0A452IVP3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGAGP00000032150.1};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000032150.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000032150.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR Ensembl; ENSGAGT00000036449.1; ENSGAGP00000032150.1; ENSGAGG00000021400.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd11808; SH3_Alpha_Spectrin; 1.
DR CDD; cd00176; SPEC; 12.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.60; -; 20.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035825; Alpha_Spectrin_SH3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF422; PH_9 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 20.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 20.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 18.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 967..1026
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2308..2343
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 2351..2386
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 290..324
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 386..416
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 858..889
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1126..1160
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1681..1715
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2160..2192
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2457 AA; 283412 MW; C74835D4EA6E00B6 CRC64;
MDPCGVKVLE TAEDIQERRQ QVLDRYHRFK ELSTLRRQKL EDSYRFQFFQ RDADELEKWI
QEKLQIASDE NYKDPTNLQG KLQKHQAFEA EVQANSGAII KLDETGNQMI NEGHFASETI
RTRLQELHRL WELLLEKMRE KGIKLLQAQK LVQYLRECED VLDWINDKEA IVTSEELGQD
LEHVEVLQKK FEEFQTDLAA HEERVNEVNQ FAGKLIQEQH PEEELIKSKQ DEVNAGWQRL
KGLALQRQGK LFGAAEVQRF NRDVDETISW IKEKEQLMAS DDFGRDLASV QALLRKHEGL
ERDLAALEDK VKALCAEADR LQQSHPHNAS QIQVKREELI ANWEHIRTLA AERHARLNDS
YRLQRFLADF RDLTSWVTEM KALINADELA NDVAGAEALL DRHQEHKGEI DAHEDSFKSA
DESGQALLAA GHYASDEVRE KLTILSDERT ALLELWELRR QQYEQCMDLQ LFYRDTEQVD
NWMSKQEAFL LNEDLGDSLD SVEALLKKHE DFEKSLSAQE EKITALDEFA TKLIQNNHYA
KEDVATRRDA LLSRRNALHE RAMYRRAQLA DSFHLQQFFR DSDELKSWVN EKMKTATDEA
YKDPSNLQGK VQKHQAFEAE LSANQSRIDA LEKAGQKLID VNHYASDEVA ARMNEVISLW
KKLLEATELK GIKLREANQQ QQFNRNVEDI ELWLYEVEGH LASDDYGKDL TNVQNLQKKH
ALLEADVAAH QDRIDGITIQ ARQFQDAGHF DADNIKKKQE ALVARYEALK DPMVARKQKL
ADSLRLQQLF RDIEDEETWI REKEPIAAST NRGKDLIGVQ NLLKKHQALQ AEIAGHEPRI
KAVTQKGNAM VEEGHFAAED VKAKLNELNQ KWESLKAKAS QRRQDLEDSL QAQQYFADAN
EAESWMREKE PIVGSTDYGK DEDSAEALLK KHEALMSDLT AYGSSMQALR EQAQSCRQQV
APTDDETGKE LVLALYDYQE KSPREVTMKK GDILTLLNST NKDWWKVEVN DRQGFVPAAY
VKKLDPAQSA SRENLLEEQG SIALRQEQID NQTLITKEVS SVSLRMKQVE ELYHSLLDLG
EKRKDMLEKS CKKFMLFREA NELQQWINEK ESALTNEEVG ADLEQVEVLQ KKFDDFQKDL
KANESRLKDI NKVANDLESE GLMAEEVQAV QQQVCDETDS KTTSPWKVGF ISIFPFQELN
ERWRSLQQMA EERSQLLGSA HEVQRFHRDA DETKEWIEEK NQALNTDNYG HDLASVQALQ
RKHEGFERDL AALGDKVNSL GETAERLIQS HPESAEDLQE KCTELNQAWN SLGKRADQRK
EKLGDSHDLQ RFLSDFRDLM SWINGIRGLV SSDELAKDVT GAEALLERHQ EHRTEIDARA
GTFQAFEQFG QQLLAHGHYA SPEIKEKLDI LDQERADLEK AWVQRRMMLD QCLELQLFHR
DCEQAENWMA AREAFLNTED RGDSLDSVEA LIKKHEDFDK AINVQEEKIA ALQSFADQLI
SADHYAKGVI SNRRNEVLDR WRRLKAQMIE KRSKLGESQT LQQFSRDVDE IEAWISEKLQ
TASDESYKDP TNIQSKHQKH QAFEAELHAN ADRIRGVIDM GNSLIDRGAC AGSEDAVKAR
LAALDDQWQF LVQKSAEKSQ KLKEANKQQN FNTGIKDFDF WLSEVEALLA SEDYGKDLAS
VNNLLKKHQL LEADISAHED RLKDLNGQAD SLMTSSAFDT SQVKDKRDTI NGRFQRIKSM
AAARRANLNE SHRLHQFFRD MDDEESWIKE KKLLVSSEDY GRDLTGVQNL RKKHKRLEAE
LAAHEPAIQG VLDTGKKLSD DNTIGKEEIQ QRLAQFVDHW KELKQLAAAR GQRLEESLEY
QQFVANVEEE EAWINEKMTL VASEDYGDTL AAIQGLLKKH EAFETDFTVH KDRVNDVCAN
GEDLIKKNNH HEENITAKIK GLRGKVSDLE KAAAQRKAKL DENSAFLQFN WKADVVESWI
GEKENSLKTD DYGRDLSSVQ TLLTKQETFD AGLQAFQQEG IANITALKDQ LLAAKHIQSK
AIEVRHASLM KRWNQLLANS AARKKKLLEA QEHFRKVEDL FLTFAKKASA FNSWFENAEE
DLTDPVRCNS LEEIKALREA HDAFRSSLSS AQADFNQLAE LDRQIKSFRV ASNPYTWFTM
EALEETWRNL QKIIKERELE LQKEQRRQEE NDKLRQEFAQ HANAFHQWIQ ETRYSLSCMV
EESGTLESQL EATKHKHQEI RAMRSQLKKI EDLGAAMEEA LILDNKYTEH STVGLAQQWD
QLDQLGMRMQ HNLEQQIQAR NTTGVTEEAL KEFSMMFKHF DKDKSGRLNH QEFKSCLRSL
GYDLPMVEEG EPDPEFEAIL DTVDPNRDGH VSLQEYMAFM ISRETENVKS SEEIESAFRA
LSSEGKPYVT KEELYQNLTR EQADYCISHM KPYMDSKGRE LTSAYDYIEF TRSLFVN
//
