ID A0A452IWE2_9SAUR Unreviewed; 659 AA.
AC A0A452IWE2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000032372.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000032372.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR STRING; 38772.ENSGAGP00000032372; -.
DR Ensembl; ENSGAGT00000036698.1; ENSGAGP00000032372.1; ENSGAGG00000023163.1.
DR Ensembl; ENSGAGT00000036699.1; ENSGAGP00000032373.1; ENSGAGG00000023163.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd08220; STKc_Nek8; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR044120; STKc_Nek8.
DR PANTHER; PTHR44535; PROTEIN CBG16200; 1.
DR PANTHER; PTHR44535:SF4; SERINE_THREONINE-PROTEIN KINASE NEK8; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00415; RCC1; 4.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50012; RCC1_3; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 1..224
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 377..428
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 429..480
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 547..598
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 599..651
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
SQ SEQUENCE 659 AA; 71441 MW; DDEF69BA728C1FD5 CRC64;
MTKDERLAAQ NECQVLKLLN HPNIIEYYEN FLEDKALMIA MEYAPGGTLA EFIHKRCNSL
LDEDTILHFF VQILLALHHV HTKQILHRDL KTQNILLDKH RMIVKIGDFG ISKILSSKSK
AYTVVGTPCY ISPELCEGKP YNQKSDIWAL GCVLYELASL KRAFEAANLP ALVLKIMSGT
FAPISDRYSP DLRQLILSML NLDPSKRPQL NEIMAQAICI RPLLNLYTDV GSVKMRRPEK
PLATVPPVTH NRAGGRVASV RPRGVRVRSA RTGIPPPLSS IYTWGSGITT PLRLPMLNTE
VVQVSAGRTQ KAGITKSGRL IMWEVSPMGA AGGPSLPGAT EQLQPQFVSR FLEGQSGVTI
KHVSCGDLFT TCLTDRGIIM TFGSGSNGCL GHGNFTDVTQ PKIVEALLGY EIVQVACGAS
HVLAISNERE VFAWGRGDNG RLGLGTLDSH NSPQQVALPP EHEAQKVLCG IDSSMVLTVK
NQILACGSNR FNKLGLDKIA EEEEPSLGDQ VEEAPTFTCV QSGPLNQEPV VCADIGTAHS
AALTASGQCY TFGSNQHGQL GTSTCHPSRV PYLVVGLQAI KVTMVACGDA FTVAIGAEGE
VYTWGKGARG RLGRKDEETR TPRPVQLEET HPYLVTSVAC CHGNTLLAVK PAGEELGPQ
//
