ID A0A452IWE8_9SAUR Unreviewed; 1077 AA.
AC A0A452IWE8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Intersectin 2 {ECO:0008006|Google:ProtNLM};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000032457.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000032457.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A452IWE8; -.
DR Ensembl; ENSGAGT00000036802.1; ENSGAGP00000032457.1; ENSGAGG00000023216.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd08375; C2_Intersectin; 1.
DR CDD; cd13264; PH_ITSN; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11988; SH3_Intersectin2_1; 1.
DR CDD; cd11990; SH3_Intersectin2_2; 1.
DR CDD; cd11992; SH3_Intersectin2_3; 1.
DR CDD; cd11994; SH3_Intersectin2_4; 1.
DR CDD; cd11996; SH3_Intersectin2_5; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035737; Intersectin-2_SH3_1.
DR InterPro; IPR035738; Intersectin-2_SH3_2.
DR InterPro; IPR035739; Intersectin-2_SH3_3.
DR InterPro; IPR035740; Intersectin-2_SH3_4.
DR InterPro; IPR035741; Intersectin-2_SH3_5.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 187..248
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 279..337
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 362..420
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 434..498
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 508..567
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 590..776
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 815..924
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 932..1048
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT COILED 23..57
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 85..186
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1077 AA; 123628 MW; 45685BCE8DA5DC3C CRC64;
ERIKHMQLDN TPNTGISSVN KKFLEKEELC QRLREQLNAL EKETASKLSE MDTFNNQLKC
ENMDDSVLQC LLSLLSCLNN LFLLLKELRE SYNTQHLALE QLQRIKQEKI RAVERKRAEL
AQKKRLEDEA ARKAKQEKEN LWQENVRKEE EEKKKRLQEE RMQEKIQEEK QKAEEAAAQV
RERENSALLV NYRALYSFEA RNNDEMSFNS GDVIQVDEKT VGEPGWLYGS FQGHFGWFPC
NYVEKISENE KALSPKRALL PPTVLLSTTS ASPEPLRTVE NLKAQALCSW TAKKDNHLNF
SKNDVITVLE KQENWWFGEV HGGRGWFPKS YVKILPGNEN KREEPETFYA AVNKKPSTPS
YTIGEEYVAL YSYTSAEPGD LTFAEGEEIL VIQKDGEWWT GSIADRTGIF PSNYVKPKDQ
DGSGTAGRTV TLNKKPEIAQ VTTAYAASGT EQLSLAPGQL ILILKKNLSG WWQGELQARG
KKRQKGWFPA NHVKLLGPSS ERTTPAALSV CQVIAMYDYA ANNEDELSFS KGQIINVLSK
DDADWWQGEI SGVTGLFPSN YVKMTTDSDP SQQWCADLQT LDTMQPMERK RQGYIHELIQ
TEERYMDDLQ LVLEVFQKRM AESGCLTEEE MGLIFVNWKE LIMSNTKLLK ALRVRKKTGG
EKMPVQMIGD ILAAELSHMQ AYIRFCSCQL NGAALLQQKT DEEIEFKDFL KKLASDPRCK
GMPLSSFLLK PMQRITRYPL LIKSILENTP ENHPDHNNLK LALERAEELC SQVNEGVREK
ENSDRLEWIQ SHVQCEGLAE QPIFNSITNC LGPRKLLHSG KLYKTKSNKE LYGFLFNDFL
LLTYMVKQFV SSGSDKLFSP KSHSQFKMYK MPIFLNEVLV KLPTDPSSDE PVFHISHIDR
VYTLKTDNIN ERTAWVQKIK GASEQYIETE KKKREKAYQA RSQKSSGIGR LMVHVIEATE
LKACKPNGKS NPYCEISMGS QSYSTRTLQD TLNPKWNFNC QFFIKDLYQD VLCITMFDRD
QFSPDDFLGR TEVPVAKIRT EQENKGPTTK RLLLHEVPTG EVWVRFDLQL FEQKTLL
//
