ID   A0A452IZ06_9SAUR        Unreviewed;       650 AA.
AC   A0A452IZ06;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Fork-head domain-containing protein {ECO:0000259|PROSITE:PS50039};
OS   Gopherus agassizii (Agassiz's desert tortoise).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Testudinidae; Gopherus.
OX   NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000033349.1, ECO:0000313|Proteomes:UP000291020};
RN   [1] {ECO:0000313|Proteomes:UP000291020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28562605;
RA   Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA   Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT   "The Agassiz's desert tortoise genome provides a resource for the
RT   conservation of a threatened species.";
RL   PLoS ONE 12:e0177708-e0177708(2017).
RN   [2] {ECO:0000313|Ensembl:ENSGAGP00000033349.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-
CC       ProRule:PRU00089}.
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DR   AlphaFoldDB; A0A452IZ06; -.
DR   STRING; 38772.ENSGAGP00000033349; -.
DR   Ensembl; ENSGAGT00000037789.1; ENSGAGP00000033349.1; ENSGAGG00000023775.1.
DR   Proteomes; UP000291020; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd20060; FH_FOXO1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR047408; FH_FOXO1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR032067; FOXO-TAD.
DR   InterPro; IPR032068; FOXO_KIX-bd.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45767; FORKHEAD BOX PROTEIN O; 1.
DR   PANTHER; PTHR45767:SF1; FORKHEAD BOX PROTEIN O1; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF16676; FOXO-TAD; 1.
DR   Pfam; PF16675; FOXO_KIX_bdg; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT   DOMAIN          153..247
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        153..247
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          111..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   650 AA;  69926 MW;  320B26BAD63EC98A CRC64;
     MAEAPQLVDI DPDFEPLPRP RSCTWPLPRP EFNPSSSATS SPAPSCGGQP DGAASASAVS
     VDFIGNLRLL EESEDFEPPP LPPAAAGAAE GAAPGGGCLC GDFQCQETGC LQQQQQPGPP
     LPQQQQHPPV SALSAGPIPG QPRKSSSARR NAWGNLSYAD LITKAIESAP EKRLTLSQIY
     EWMVKSVPYF KDKGDSNSSA GWKNSIRHNL SLHSKFIRVQ NEGTGKSSWW MLNPEGGKSG
     KSPRRRAASM DNNSKFAKSR GRAAKKKAAL QSSQEGNGDS PGSQFSKWPA SPSSHSNDDF
     DNWSTFRPRT SSNASTISGR LSPILPEQDD LGDGDVHSMV YPSSATKMAS TLPSLSEMSN
     SENMENLLDN LNLLSPSTSL TVSTQSSPAT MMQQTPGYSF ASPTTSIGSP NPDYRKFTYA
     QASMNALPQM PMQTLQDSKS SYGTISQYNC PAGLLKELLT SDSPPHNDIL TSVDTGVSQP
     SGRVLGQNVL MVTDSVMSTY GNQPSHNKMM TPSAHPHQGR NQPTVAVNGR ALSHTVNTMS
     HTSGLNRLST VKTSLQVPMS HPMHMNTMNP YAAVNSCNGY GRVGIVSLHQ EKLPSDLDDM
     LIERLDCDME SIIRNDLMDG ETLDFNFDSV LPNQSFPHSV KTTTHSWVSG
//