ID A0A452J0F1_9SAUR Unreviewed; 1945 AA.
AC A0A452J0F1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Myosin heavy chain 6 {ECO:0008006|Google:ProtNLM};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000033836.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000033836.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Muscle contraction. {ECO:0000256|ARBA:ARBA00037488}.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2).
CC {ECO:0000256|ARBA:ARBA00038612}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 38772.ENSGAGP00000033836; -.
DR Ensembl; ENSGAGT00000038325.1; ENSGAGP00000033836.1; ENSGAGG00000020688.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 5.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF11; MYOSIN-6; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT DOMAIN 44..93
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 97..786
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 663..685
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 848..1164
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1208..1931
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 190..197
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1945 AA; 225132 MW; C9A35D7F3764D0C9 CRC64;
NSLFCILTYR IIYWMMDMSE FGEAAPFLRK SDKEIMILQT VAFDGKRRCW IPDEKKAYTE
GDIKESSGGK VTVETVDGKT VTVKEDDVQP MNPPKFDMIE DMAMLTHLNE ASVLHNLNRR
YSHWMIYTYS GLFCVTINPY KWLPVYNPEV VNAYKGKRRS EAPPHIFSIA DNAYNDMLRN
RENQSMLITG ESGAGKTVNT KRVIQYFATV AALGEPGKKS GTLEDQIIQA NPALEAFGNA
KTLRNDNSSR FGKFIRIHFG TTGKLSSADI EIYLLEKSRV IFQQPGERSY HIFYQILSGK
KAELQDMLLV STNPYDYHFS SQGAVTVDNL DDGEELMATD QAMDILGFIP DEKYGAYKLT
GSIMHFGNMK FKQRPREEQA ETDGTESTDK AAYLMGLNSS DLAKGLLHPR VKVGNEYVTK
GQSVEQVVYA VGALSKAVYD RMFKWLVIRI NKTLDTRLPR QFFIGVLDIA GFEIFDYNSF
EQLCINYTNE KLQQFFNHHM FVLEQEEYKK EGIEWVFIDF GLDLQACIDL IEKPLGILSI
LEEECMFPKA TDMTFKAKLY DNHLGKSPNL QKPRIDKKRK YEAHFELLHY AGAVPYNIIG
WLEKNKDPLN ETVVGIFQKS ANKLLASLFE NYVSADSVDH STEKKRKKGA SFQTVSSLHK
ENLNKLMTNL RSTAPHFVRC IIPNETKTPG AMDAYLVLHQ LRCNGVLEGI RICRKGFPNR
VLYADFKQRY RILNPAAIPE DKFVDSRKAS EKLLASLDID QTQYRFGHTK VFFKAGLLGH
LEEMRDHRLS KILTMIQARA RGKLMRIEFQ KIVERRDALL VIQWNIRAFM AVKNWPWMKL
FFKIKPLLKS AETEKEMANM KEEFLKLKEA LEKSEARRKE LEEKQVSLVQ EKNDLLLQLQ
AEQDTLADAE ERCDLLIKSK IQMEAKVKEL TERVEDEEEM NSELTSKKRK LEDECSELKK
DIDDLEITLA KVEKEKHATE NKVKNLTEEM ASLDETISKL TKEKKSLQEA HQQALDDLQA
EEDKVNTLSK TKLKLEQQVD DLEGSLEQEK KIRMDLERVK RKLEGDLKLT QESLMDLEND
KLQLDEKLKK KEFEINQLNS KLEDEQTIVM QLQKKIKELQ ARIEELEEEL EAERAARAKV
EKQRSDLARE LEELSERLEE AGGATAAQLE MNKKREAEFL KVRRDLEEAT LHYEATAATL
RKKHADSMAE LGEQVDNLQR VKQKLEKEKS ELKLEVDDLL SNMEQMVKGK SNAEKLCRTY
EDNLNETKTK LDEMTRLMND LTTQKGKLQT ENGEFARQLE EKESLISQLS RGKTSFTQQI
EELRRLLEEE TKSKNALAHA LQAARHDCDL LREQFEEEQE AKAELQRALS KGNAEVAQWR
TKYETDAIQR TEELEEAKKK LAARLQEAEE AIEAANAKCS SLEKTKHRLQ NELEDIVIDL
ERANSAAAAL DKKQRNFDKL ISDWKQKYEE TQAELEASQK EARSLSTELF KLKNAYEETL
DNLETVKREN KNLQEEISDL TDQISEGNKS LHEIEKIKKQ VEQEKSEVQL ALEEAEGALE
HEESKSLRFQ LEISQIKAEF ERKLAEKDEE MENIRRNQQR TIDSLQSTLD SEAKSRNEAI
RLKKKMEGDL NEMEIQLSHA NRHASEATKS ARILQAQIKD LQVQLDDSEH LNEDLKEQLA
VTDRRNNLIQ SELDELRALL DQTERGRKLA EQELLEATER VNLLHTQNTS LINQKKKLET
DISQMQNEVE EAIQECRNAE EKAKKAITDA AMMAEELKKE QDTSAHLERM KKNMEQTIKD
LQKRLDEAEQ IALKGGKKQI QKLESRVREL ENDLENELRR NTESQKGVRK YERRIKELTY
QAEEDKKNLT RMQELIDKLQ LKVKSYKHQA EEAEAQSNQY LAKYRKQQHE LDDAEERAEI
AESQVNKLRT KTRDIGIKKV HEEEE
//
