ID A0A452J1C0_9SAUR Unreviewed; 832 AA.
AC A0A452J1C0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Taste receptor type 1 member 2 {ECO:0000256|ARBA:ARBA00040704};
DE AltName: Full=Sweet taste receptor T1R2 {ECO:0000256|ARBA:ARBA00042616};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000034190.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000034190.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC natural and synthetic sweeteners. {ECO:0000256|ARBA:ARBA00037659}.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3.
CC {ECO:0000256|ARBA:ARBA00038699}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000256|ARBA:ARBA00038492}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452J1C0; -.
DR Ensembl; ENSGAGT00000038716.1; ENSGAGP00000034190.1; ENSGAGG00000024281.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF517; TASTE RECEPTOR TYPE 1 MEMBER 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 557..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 721..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..773
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 558..824
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 832 AA; 94223 MW; 487FA23848DB6181 CRC64;
MGPLASCLSH YVLLTMAGSQ TQYSDFHLAG DYLLGGLFSL HTETKSSPHL SYSAVPTCQA
YKLKKASYSH LRAMRFAVEQ INNSSTLLPG VSLGYEMVDV CYLTNFIHPI LYFLANKHSV
VQLHNNYTHY QPRVLAVIGP DSSQAVVIAA QVLSLFLVPQ ISYTATTNEL SDRKRFPTAF
QTISSMEQQI VAMQLLLKEF RWNWINILYS DDDYGRQNLK LLRARATEIC VALQEVIPVP
QSSQMLSLEL QGKIKSVVRK VIHSTAKVVI VLSLELILPF FFQEAVRQNV TDLVWIATEA
WATEPALYNI TDLWRLGTIL GVAVKEFSIP GLDDFRVSLA EGANEQASDQ TTCNQECDQC
LRAAQDAEHS MRAQGERTDF SVYSSVYIVA HALHRLLGCN TTGCHKRMVY PWQLVPEVKR
VNFSLLNERI NFRERGTIPN SFEIIQWKWD QPNNPFQKIA SYSRNKKLLF TIQNISWHTP
NNTVPISVCS QQCEYGQRRK PVTVSSCCFE CIDCEEGTFL NNNDLYNCQP CPADQWSNAR
SQKCYPRLLK YLEWQEGIAV VLLLFSVLGL VATVVISVIF AIHLHTPVVK SAGGRMCFLM
LASLIIGFIN VPVYMGIPTE FKCMCRQIVY TLCFTVCISC LTVRSFQIIS IFKMAARLPK
AYSYWMKYNG QYIFITVILA LKVTIVVTNV IIHPSIPVPL VLEDDPSTVE LQCNKSFKLS
LLMNNSLDTF LSILCFYFSY IGKELPKNYN EAKYITLCMT CYAVSEIAIF LAMSVYRGML
VTICDVIGVV INLLGISIGY FGPKCYLIFF HPERNTAAYF QSVIQSYTMR QD
//
