ID A0A452J4Y0_9SAUR Unreviewed; 806 AA.
AC A0A452J4Y0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGAGP00000035516.1};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000035516.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000035516.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A452J4Y0; -.
DR Ensembl; ENSGAGT00000040223.1; ENSGAGP00000035516.1; ENSGAGG00000025235.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..806
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019357923"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..225
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 326..513
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 292..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 89768 MW; D8F6E0AE2EA88F62 CRC64;
FSFLLVFGCL ILSVFSTIPE HAKLASRCLF ILEFVMIVVF GFEYIIRIWS AGCCCRYRGW
QGRLRFARKP FCVIDTIVLI ASIAVVSAKT QGNIFATSAL RSLRFLQILR MVRMDRRGGT
WKLLGSVVYA HSKELITAWY IGFLVLIFSS FLVYLVEKDA NTQFSTYADA LWWGTITLTT
IGYGDKTPLT WLGRLLSAGF ALLGISFFAL PAGILGSGFA LKVQEQHRQK HFEKRRNPAA
SLIQCVWRSY AADEKSVSIA TWKPHLKALH TCSPTNKLCS NKQKLFRMYS SRKHSQKLSF
KERVRMASPR GQSIKNRQAS VGDRRSPGTD VTAESSPTKV QKSWSFNDRT RFRPSLRLKS
SQPKPVADAD TTLGTDDVCD ERGCQCDVSV EDLTPALKTI IRAIRIMKFH VAKRKFKETL
RPYDVKDVIE QYSAGHLDML CRIKSLQSRV DQILGKGQIT TDKKSREKNT AENETTDDFS
MLGRVVKVEK QVQSIESKLD SLLDIYQQVL RKGSASALTL ASFQMPSFEC DQTSDYQSPV
DSKDLSSSAQ TSGCVSRSAS ANMTRGLQLI LTPNEFSTQA YYAFSPTMHS QATQVPNDEP
ATVITNNTSN QINQATKPTT PTTLQIPPFS SVKDANWPEP LHIIPATTQE NISDVTACLV
ALKDNGQVAQ SKVTKDLSWR KNLDTEGEPL VSVKPVVQMD LGKSLSVQNL IQSSEELNVH
IAGSDSSGSR GSQEVYSKWR ESKLFITDEE LEAETKTEAF ESISRSLVET ALSTDSLRTG
ISRSSQSICK PGDSTDALSL PHVKLK
//
