ID A0A452J5K0_9SAUR Unreviewed; 1174 AA.
AC A0A452J5K0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGAGP00000035758.1};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000035758.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000035758.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A452J5K0; -.
DR Ensembl; ENSGAGT00000040485.1; ENSGAGP00000035758.1; ENSGAGG00000025255.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR002444; NKCC1.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF58; SOLUTE CARRIER FAMILY 12 MEMBER 2; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
DR PRINTS; PR01208; NAKCLTRSPRT1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..214
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 251..753
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 762..1174
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..950
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 128035 MW; 389A8D48AC2CE176 CRC64;
PLTPPARPRV ALKTQPRAAA RSGGGAEETS RLPAREGDVP AAGAEPEAGL SPAAAAGDAL
CRPLGPSQSR FQVDLVAEGA GRAAADEPQK PAGQGAAAAK GSEEAKGRFR VNFVDPSAGD
ESPAEHGGGL EGGGVNFQNG GDTVLSEGSL HSGGGGHHHY YYDTHTNTYY LRTFGHNTMD
AVPRIDHYRH TAAELGEKLI RPSLAELHDE LDKEPFEDGY ANGEDGTPPG EADATYAADS
KGIVKFGWIK GVLVRCLLNI WGVMLFIRLS WIVGQAGIAL SVLVIAMATV VTTITGLSTS
AIATNGFVRG GGAYYLISRS LGPEFGGAIG LIFAFANAVA VAMYVVGFAE TVVELLQENG
ALMLDQMNDI RIIGAITVLV LLGISVAGME WEAKAQIVLL VILLFAVGDF IIGTFIPLDS
KKVKGFFGYK AEIFTENFGP DFRADETFFS VFAIFFPAAT GILAGANISG DLADPQSAIP
KGTLLAILIT TIVYMGIAVS VGACVVRDAT GNINSTIITE LTNCTTAACK LNFDFSSCQK
TKCHYGLLNN FQVMSMVSGF APLISAGIFS ATLSSALASL VSAPKIFQAL CKDNIYPGLL
MFAKGYGKNN EPLRGYILTF LIALGFILIA ELNVIAPIIS NFFLASYALI NFSVFHASLA
KSPGWRPAFK YYNMWVSLIG AILCCIVMFV INWWAALLTY VIVLGLYIYV TYKKPDVNWG
SSTQALTYLS ALQHTVRLAG VEDHVKNFRP QCLVMTGAPN SRPALVHLVH AFTKNVGLMI
CGHIHMGPRR QAMKELSTDL ARYQRWLIKN KMKAFYAPVH AEDLRDGGQY LMQAAGLGRM
RPNTLVVGFK KDWKQADMRD VETYINLFHD AFDIQYGVVV IRLKEGLDIS HLQGQEELLS
SQEKSPSSRD VVVNVDYSKK TETDTSKAFS PPSSEKTPEE EEDGKTPTQP LLKKDSKGPR
APLNLADQRL LDASSQFQKK QGKNTIDVWW LFDDGGLTLL IPYLLTTKKK WKDCKIRVFI
GGKINRIDHD RRAMATLLSK FRIDFSDIMV LGDINTKPKK ENIAAFEEMV EPFRLHEDDK
EQDIADKMKD DEPWRITDNE LELYKTKSYR QIRLNELLKE HSSTANVIVM SLPVARKGAV
SSALYMAWLE ALSKDLPPVL LVRGNHQSVL TFYS
//