ID A0A452J6Y8_9SAUR Unreviewed; 637 AA.
AC A0A452J6Y8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Netrin-1 {ECO:0000256|ARBA:ARBA00015919};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000036267.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000036267.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR STRING; 38772.ENSGAGP00000036267; -.
DR Ensembl; ENSGAGT00000041056.1; ENSGAGP00000036267.1; ENSGAGG00000025699.1.
DR Ensembl; ENSGAGT00000041058.1; ENSGAGP00000036269.1; ENSGAGG00000025699.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 3.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF431; LAMININ G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 3.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..637
FT /note="Netrin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040683376"
FT DOMAIN 33..269
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 270..334
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 335..397
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 398..451
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 515..636
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 298..307
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 365..374
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 425..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 637 AA; 71229 MW; A1B2058ACD0CFFBB CRC64;
MQHKGIMLIV FLEYFVSGLG EADPVKLRTF RCDGHSCNPP VGNLATGRTP VSLTTCGQNS
TELYCFYSDQ HLFHWASQGC GQPQCTKCNA NQPDNSHLPS DMTDDFFLNP GSWWQSAQGV
HREEIRLDLE TAFYLTHVIV VFKSPRPAAM VLERSQDNGQ TWRSYKYFSS NCTATFGLQD
DLIEEGSLCT SRYSDAVPCT RGEVIYRALT PTNKIEDPYG PEAQDLLKLT NLRLLLLKRQ
ECPCQGLGLL EKPQRFAHYA IYDLIVRGSC FCNGHAEECQ LANGTGNTEN VVHGKCVCRH
NTAGNHCERC EPLYNDQPWK PGDGKTGAPN ECRKCRCHNH ADSCHFNLSV WLASGKHSGG
ICDNCKHNTE GHRCQRCKPG FYRDRGKPMS SPEVCKPCSC QPMGSANATF SRSWRCHPKT
GFCYCKPGVA GPNCDRCLMG YWGLGENGCR PCDCARDCNP HTGNCFNGYD NEPFFNIPMG
GRIPDLLQMP ANESDEWKWN DHEQGFSALR HPEKCVCKEK VLGSVTDFCQ MKYAYVIKAR
ILSAHDKGTH AEVVVKVKKV LKSGKVKIAR SNRSIYPESW TNRGCTCPIL NPGTEYLIAG
QEDSRTSKLL VNMNSLVKPW KAYLGKQVAD ILRTGCK
//
