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Database: UniProt
Entry: A0A452J7B3_9SAUR
LinkDB: A0A452J7B3_9SAUR
Original site: A0A452J7B3_9SAUR 
ID   A0A452J7B3_9SAUR        Unreviewed;       473 AA.
AC   A0A452J7B3;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Keratin, type I cytoskeletal 14 {ECO:0000256|ARBA:ARBA00040326};
DE   AltName: Full=Cytokeratin-14 {ECO:0000256|ARBA:ARBA00041705};
DE   AltName: Full=Keratin-14 {ECO:0000256|ARBA:ARBA00042490};
OS   Gopherus agassizii (Agassiz's desert tortoise).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Testudinidae; Gopherus.
OX   NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000036385.1, ECO:0000313|Proteomes:UP000291020};
RN   [1] {ECO:0000313|Proteomes:UP000291020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=28562605;
RA   Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA   Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT   "The Agassiz's desert tortoise genome provides a resource for the
RT   conservation of a threatened species.";
RL   PLoS ONE 12:e0177708-e0177708(2017).
RN   [2] {ECO:0000313|Ensembl:ENSGAGP00000036385.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: The nonhelical tail domain is involved in promoting KRT5-
CC       KRT14 filaments to self-organize into large bundles and enhances the
CC       mechanical properties involved in resilience of keratin intermediate
CC       filaments in vitro. {ECO:0000256|ARBA:ARBA00037229}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   AlphaFoldDB; A0A452J7B3; -.
DR   STRING; 38772.ENSGAGP00000036385; -.
DR   Ensembl; ENSGAGT00000041205.1; ENSGAGP00000036385.1; ENSGAGG00000025794.1.
DR   Proteomes; UP000291020; Unassembled WGS sequence.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR   PANTHER; PTHR23239:SF368; KERATIN, TYPE I CYTOSKELETAL 14; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT   DOMAIN          121..432
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          125..159
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          224..350
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          376..417
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   473 AA;  51597 MW;  709C7E8B416606CF CRC64;
     MTTSVRQYSS STSLKGLGGL SGLGGGSTRV SSVNLGGPYR APSIHGGSGG FSVSSSRYVS
     GVGSSLGGGY GGSYSSSFGG GYGGGLGGGY GGCLGGGLGG GYGVGFGGGF GGGDGILPAG
     EKETMQNLND RLATYLDKVR ALEEANSDLE IKIKEWYKKQ GPSPDRDYSP YYRTIEDLRS
     KILSATVDNA SLLLQIDNAR LTADDFRTKF ETEQALRMSV EADINGLRRV LDELTLARAD
     LEMQIENLKE ELAYLKKNHE EEMKILRSQL GGDITVEMDA APGVDLTKIL ADMREQYESL
     AEKNRKEAEQ WFYTQTEQLN REVAMNTEQL QSGKSEITEL RRTVQGLEIE LQSQLSMKAA
     LEGTLAETEA RYGTQLAQLQ ALITSVEEQL AELRCDMERQ NHEYKILVDV KTRLEQEIAT
     YRRLLEGEDA HIASQYALAK EASMTTRQVR TIVEEVQDGK VISSREQVHH SSR
//
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