ID A0A452J7J2_9SAUR Unreviewed; 607 AA.
AC A0A452J7J2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Kinetochore protein NDC80 {ECO:0000256|RuleBase:RU368072};
OS Gopherus agassizii (Agassiz's desert tortoise).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Testudinidae; Gopherus.
OX NCBI_TaxID=38772 {ECO:0000313|Ensembl:ENSGAGP00000036481.1, ECO:0000313|Proteomes:UP000291020};
RN [1] {ECO:0000313|Proteomes:UP000291020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=28562605;
RA Tollis M., DeNardo D.F., Cornelius J.A., Dolby G.A., Edwards T.,
RA Henen B.T., Karl A.E., Murphy R.W., Kusumi K.;
RT "The Agassiz's desert tortoise genome provides a resource for the
RT conservation of a threatened species.";
RL PLoS ONE 12:e0177708-e0177708(2017).
RN [2] {ECO:0000313|Ensembl:ENSGAGP00000036481.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|RuleBase:RU368072}. Nucleus
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family.
CC {ECO:0000256|ARBA:ARBA00007050, ECO:0000256|RuleBase:RU368072}.
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DR AlphaFoldDB; A0A452J7J2; -.
DR STRING; 38772.ENSGAGP00000036481; -.
DR Ensembl; ENSGAGT00000041314.1; ENSGAGP00000036481.1; ENSGAGG00000025875.1.
DR Proteomes; UP000291020; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.250.1950; -; 1.
DR Gene3D; 1.10.418.30; Ncd80 complex, Ncd80 subunit; 1.
DR InterPro; IPR040967; DUF5595.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR PANTHER; PTHR10643; KINETOCHORE PROTEIN NDC80; 1.
DR PANTHER; PTHR10643:SF2; KINETOCHORE PROTEIN NDC80 HOMOLOG; 1.
DR Pfam; PF18077; DUF5595; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368072};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU368072};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU368072};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU368072};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838, ECO:0000256|RuleBase:RU368072};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU368072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368072};
KW Reference proteome {ECO:0000313|Proteomes:UP000291020}.
FT DOMAIN 215..286
FT /note="DUF5595"
FT /evidence="ECO:0000259|Pfam:PF18077"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 266..293
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 329..401
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 466..539
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 607 AA; 69925 MW; 909E9AC08D8E72CA CRC64;
MRRSSSTTGS SSRQSVMPLR VQDTNKMGLH TPQAQDRTNF GKLSMSKPAS GTSERKISFF
GKRTSGPGGS RNSQYGVFGT EKIKDPRPLH DKAFIQQCIR QLCEFLVENG YAHNVSMKSL
QSPSVKDFLK IFTFIYGFLC PYELPDSKFE EEIPRIFKEL GYPFALSKSS MYTVGAPHTW
PQIVAALVWL IDCVKLYSAM RENTPFDEGQ TWEGETEDGI VHHKLFMDYT VKCYEHFMKG
GDTFEEFDAE VQLKLKDLFN VDEFQVEALA AENKRLHEEI ARLEKERESE PDRLVSLKKL
KSSLQADVQK YQAYMANLES HAAILDQKVK GINGQLETAE MEVEAMKQEN ARLQHIFDNQ
KYSVADIERI NHERDELQQT INKLTKELEA EEHQLWNEEM KYARGKEAIE TQLAEYHKLA
RKLKLIPISA ENSKGHDFEI KFNPEAGPNC LVKYRTHINA PLMELINRTE EEIRKATHKK
MGLEDTLEQV NTMVLEKKSR VKMLKEEAQK LDDLYHQKLK EAEEEEKKCA TELELLEKHK
HLLESGINEG LSEAMNELHD VQRQYQVVMQ MTTEESRKVG DNLNRLLEVI ATHVVSVEVS
QTCCCLQ
//
