ID A0A452Q8S2_URSAM Unreviewed; 582 AA.
AC A0A452Q8S2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Lamin B2 {ECO:0000313|Ensembl:ENSUAMP00000000678.1};
GN Name=LMNB2 {ECO:0000313|Ensembl:ENSUAMP00000000678.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000000678.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000000678.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452Q8S2; -.
DR STRING; 9643.ENSUAMP00000000678; -.
DR Ensembl; ENSUAMT00000000778.1; ENSUAMP00000000678.1; ENSUAMG00000000645.1.
DR GeneTree; ENSGT00940000160274; -.
DR OMA; EMTQMRD; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR PANTHER; PTHR45721:SF2; LAMIN-B2; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF00932; LTD; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 1..409
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 446..565
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..232
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 264..384
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 64069 MW; C4F25F738A6A909E CRC64;
MTLCRAVQPS PLSNSGTVPS SKRSPAPISC HPHPLPRPPA SPLRVRRGTG DLGGSGRLGS
PPGGRRREKP CPARGHPLSV GKGFLPDLGL AAPPQVSGIK TLYEAELADA RRVLDETARE
RARLQIELGK LKAELEEANK SSKKREGELT VAQGRVKDLE SLFHRSEAEL AAALSDKRGL
ESDVAELRAQ LAKAEDGHAV AKKQLEKETL MRVDLENRCQ SLQEELDFRK NVFEEEVRET
RRRHERRLVE VDSSRQQEYD FKMAQALEEL RSQHDEQVRL YKLELEQTYQ AKLDSAKLSS
DQNDKAASAA REELKEARMR LESLSYQLSG LQKQASAAED RIRELEETMA GERDKFRKML
DAKEQEMTEM RDVMQQQLAE YQELLDVKLA LDMEISAYRN SSSSSVSTAG RSGRSKRKRL
EAEESPGPGS SGIGSGGSSS SSSTSFHLAQ QASASGGVSI EEIDLEGRFV QLKNSSDKDQ
SLGNWRIKRQ VLEGEEIAYK FTPKYVLRAG QTVTVWAAGA GVAHSPPSTL VWKSQNSWGT
GESFRTILLN ADGEVGACAS LGVAGLSFQG DPRTTSRGCR VM
//
