ID A0A452Q923_URSAM Unreviewed; 785 AA.
AC A0A452Q923;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000000800.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000000800.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452Q923; -.
DR Ensembl; ENSUAMT00000000916.1; ENSUAMP00000000800.1; ENSUAMG00000000719.1.
DR GeneTree; ENSGT00940000163837; -.
DR OMA; LCNEAFC; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF259; PROTOCADHERIN GAMMA-B3-RELATED; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..785
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019476456"
FT TRANSMEM 669..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..133
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 134..229
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 230..334
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 335..439
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 446..541
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 556..654
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 785 AA; 85368 MW; F1B7308C00670ADF CRC64;
MGDLLGQKGP TGRRRMRFLF LLSLVCPVLP EQIRYTIPEE LAMGSLVGNL PKDLGLGVQD
LPTRNLRISA QKKFFTVSTE NGDLLVSDRI DREQICGKKS SCVLEFEMVA EKPLNFFHIS
VVIQDINDNP PTFSQNITEL EISELALTGA TFSLESAQDS DVGVNSLQQY YLNPNPHFSL
IQKENPDGSR YPELVVKTPL DREEQSCHHL VLTAIRVLVA DANDNPPVFT QDVYRASVRE
NLPMGSSVLS VMATDLDEGV NAEITYAFIN TGNVVRQLFK LDSKTGVLTT GGELDFEERE
SYTIGVEAKD GGRHTAHCKI QIDILDENDN APEVTLDSES KQIQEDAELG TVVALIKTHD
LDSGFNGEVF CQLQGKFPFK IVQDTKNTYM LVTDGVLDRE QIPEYNITIT VTDRGKPPLS
SNRSVLLNII DVNDNAPVFG QAFCLVHVAE NNPPGASIAQ VSASDPDLGP NGRVSYSIVA
SDLEPRALAS YVSVSAQSGV VFQLRAFELT LQARDQGSPA LSANVSLRVL VDDRNDNAPR
VLYPALGPDG SALFDTVPRA AQPGYLVTKV VAVDADSGHN AWLSYHVLQA SEPGLFSLGL
RTGEVRTARA LGDRDAARQR LLVAVRDGGQ PPLSATATLN LAFADSLQEV LPDVSDRPAP
SDPQAELQFY LVVALALISV LFLLAVILAV ALRLGRSSSP AAWGCFQTNV CSKTESGVLP
NFIEGTLPYS YNLCAASHSS KTEFKFLNIK PDNVPPQDLL CNEASWFEST SDEDPQMTSN
SVSSL
//
