ID A0A452Q975_URSAM Unreviewed; 516 AA.
AC A0A452Q975;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Cell division cycle 20 {ECO:0000313|Ensembl:ENSUAMP00000000868.1};
GN Name=CDC20 {ECO:0000313|Ensembl:ENSUAMP00000000868.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000000868.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000000868.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family.
CC {ECO:0000256|ARBA:ARBA00006445}.
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DR AlphaFoldDB; A0A452Q975; -.
DR STRING; 9643.ENSUAMP00000000868; -.
DR Ensembl; ENSUAMT00000000993.1; ENSUAMP00000000868.1; ENSUAMG00000000861.1.
DR GeneTree; ENSGT00950000183104; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000776; C:kinetochore; IEA:Ensembl.
DR GO; GO:0033597; C:mitotic checkpoint complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IEA:Ensembl.
DR GO; GO:0097027; F:ubiquitin-protein transferase activator activity; IEA:InterPro.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:Ensembl.
DR GO; GO:1990949; P:metaphase/anaphase transition of meiosis I; IEA:Ensembl.
DR GO; GO:0007064; P:mitotic sister chromatid cohesion; IEA:Ensembl.
DR GO; GO:0090307; P:mitotic spindle assembly; IEA:Ensembl.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IEA:Ensembl.
DR GO; GO:0090129; P:positive regulation of synapse maturation; IEA:Ensembl.
DR GO; GO:0031915; P:positive regulation of synaptic plasticity; IEA:Ensembl.
DR GO; GO:0040020; P:regulation of meiotic nuclear division; IEA:Ensembl.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1.
DR PANTHER; PTHR19918:SF3; CELL DIVISION CYCLE PROTEIN 20 HOMOLOG; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 239..280
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 240..295
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 322..353
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 456..487
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 516 AA; 56432 MW; AC8C23D5F7A77D2E CRC64;
MHPPRAGSAK LRKPRGRPPH PCVRPTDPTA PAGPQAELPV RGVRRDIGKG QGMAESGLRA
SSPRSLVRLS GFPLPAPGKS SSKAQTTPSK PGGDRYIPHR SASQMEVASF LLSKENQPED
SQTPTKKEHQ KAWALNLNGF DVEEAKILRL SGKPQNAPEG YQNRLKVLYS QKATPGSSRK
TCRYIPSLPD RILDAPEIRN DYYLNLVDWS SGNVLAVALD NSVYLWSASS GDILQLLQME
QPGDYISSVA WIKEGNYLAV GTSNAEVQLW DVQQQKRLRN MTSHSARVSS LCWNSYIVSS
GSRSGHIHHH DVRVAEHHVA TLSGHSQEVC GLRWAPDGRH LASGGNDNLV NVWPSAPGEG
GWVPLQTFTQ HQGAVKAVAW CPWQSNVLAT GGGTSDRHIR IWNVCSGACL SAVDAQSQVC
SILWSPHYKE LISGHGFAQN QLVIWKYPTM AKVAELKGHT ARVLSLTMSP DGATVASAAA
DETLRLWRCF ELDPARRRER EKASAAKNSL IHQGIR
//
