ID A0A452Q9V0_URSAM Unreviewed; 399 AA.
AC A0A452Q9V0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Cytohesin 1 {ECO:0000313|Ensembl:ENSUAMP00000001152.1};
GN Name=CYTH1 {ECO:0000313|Ensembl:ENSUAMP00000001152.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000001152.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000001152.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452Q9V0; -.
DR Ensembl; ENSUAMT00000001331.1; ENSUAMP00000001152.1; ENSUAMG00000000737.1.
DR GeneTree; ENSGT00940000157519; -.
DR OMA; IPDNKDR; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF340; CYTOHESIN-1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 57..244
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 262..378
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 15..56
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 399 AA; 46607 MW; 545E1524D5B3395E CRC64;
LLLKERGRYT SSDLTAEERQ ELENIRRRKQ ELLADIQRLK DEIAEVANEI ENLGSTEERK
NMQRNKQVAM GRKKFNMDPK KGIQFLIEND LLKNTCEDIA QFLYKGEGLN KTAIGDYLGE
RDEFNIQVLH AFVELHEFTD LNLVQALRQF LWSFRLPGEA QKIDRMMEAF AQRYCQCNNG
VFQSTDTCYV LSFAIIMLNT SLHNPNVKDK PTVERFIAMN RGINDGGDLP EELLRNLYES
IKNEPFKIPE DDGNDLTHTF FNPDREGWLL KLGGRVKTWK RRWFILTDNC LYYFEYTTDK
EPRGIIPLEN LSIREVEDSK KPNCFELYIP DNKDQVIKAC KTEADGRVVE GNHTVYRISA
PTPEEKEEWI KCIKAAISRD PFYEMLAARK KKVSSTKRH
//
