ID A0A452QB08_URSAM Unreviewed; 558 AA.
AC A0A452QB08;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Tyrosine kinase with immunoglobulin like and EGF like domains 1 {ECO:0000313|Ensembl:ENSUAMP00000001341.1};
GN Name=TIE1 {ECO:0000313|Ensembl:ENSUAMP00000001341.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000001341.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000001341.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A452QB08; -.
DR Ensembl; ENSUAMT00000001545.1; ENSUAMP00000001341.1; ENSUAMG00000000981.1.
DR GeneTree; ENSGT00940000157693; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR26391; INACTIVE TYROSINE-PROTEIN KINASE 7; 1.
DR PANTHER; PTHR26391:SF18; PROTEIN KINASE RECEPTOR TIE-1, PUTATIVE-RELATED; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 2.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50853; FN3; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 85..116
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 171..205
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 306..403
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 405..502
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 536..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 106..115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 195..204
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 558 AA; 60664 MW; A506B0F417F1A214 CRC64;
TAVLVARVRK EKQTDVIWKS NGSYFSTLDR HEAQDGRFLM QLPNVQPPAS GVYSATYLET
SPLGSAFFRL IVRGCGAGRW GPDCTKECPG CLHGGVCHDQ DGECVCPPGF TGTRCEQACR
EGRFGQRCQE QCPGTSGCRG LTFCLPDPYG CSCGSGWRGS QCQEACAPGH FGADCRLQCQ
CRNGGTCDRF SGCVCPSGWH GMHCEKSDRI PQILDVASEL EFNLETTPRI NCAAAGNPFP
VRGSMELRKP DGTVLLSTKA IVEPDRTTAE FEVPRLALGD SGLWECRVST SGGQDSRRFR
VNVKVPPVPL TAPRLLAKQS RQLVVSPLVS FSGDGPIASV RLHYRPQEGD LAWSAIVVDP
SENVTLMNLR PKTGYSVRVQ LSRPGEGGEG VWGPPTLMTT DCPEPLLQPW LEGWHVEGPD
RLRVSWSLPS VPGPMVGDGF LLRLWDGTRG QERRENVSSP QARTALLTGL TPGTHYQLDV
RLYHCALLGP ASPPARVLLP PSGKLEKMGK PGFMWRSRVM ARMWCTRRTW DLGEHRAQGA
WGGPSMLGGP GPPGRPGT
//
