ID   A0A452QDJ0_URSAM        Unreviewed;       929 AA.
AC   A0A452QDJ0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Bromodomain containing 8 {ECO:0000313|Ensembl:ENSUAMP00000002410.1};
GN   Name=BRD8 {ECO:0000313|Ensembl:ENSUAMP00000002410.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000002410.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000002410.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A452QDJ0; -.
DR   Ensembl; ENSUAMT00000002750.1; ENSUAMP00000002410.1; ENSUAMG00000002193.1.
DR   GeneTree; ENSGT00530000064262; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   CDD; cd05507; Bromo_brd8_like; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR   InterPro; IPR037966; Brd8_Bromo_dom.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   PANTHER; PTHR15398; BROMODOMAIN-CONTAINING PROTEIN 8; 1.
DR   PANTHER; PTHR15398:SF4; BROMODOMAIN-CONTAINING PROTEIN 8; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 1.
DR   SUPFAM; SSF47370; Bromodomain; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          775..845
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   REGION          190..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          584..723
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          878..900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          76..110
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        190..207
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        590..604
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..640
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        648..662
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        690..704
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   929 AA;  100762 MW;  806EE0AD9D8D2D54 CRC64;
     MAAGTGSKTQ AAEYWPYRAM VHPREALFSL FSYEEWRSKL HCASQYSELL ETTETPKRKR
     GEKGEVVETV EDVIVRKLTA ERVEELKKVI KETQEKYRRL KRDAELIQAG HMDSRLDELC
     NDIVMRKKLE EEEAEVKRKA TDAAYQARQA VKTPPRRLPT VMVRSPIDSA SPGGDYPLGD
     LTATTMEEAT SGVTPGTLPS TPVTSFPGIP DTLPPGSAPL EAPMTPVTDD SPQKKMLGQK
     ATPPPSPLLS ELLKKGSLLP TSPRLVNESE MAVASGHLNS TGVLLEVGGV LPMIHGGEMQ
     QTPNTVAASP AASGAPTLSR LLEAGPTQFT TPLASFTTVA SEPPVKLVPP PVESVSQATI
     VMMPALPAPS SAPAVSTPES VAPVSQPDTC VPMEAVGDPH TVTVSMDSSE ISMIINSIKE
     ECFRSGVAEA PGGSKAPSID GKEDLDLAEK MDIAVSYTGE ELDFETVGDI IAIIEDKVDD
     HPEVLDVAAV EAALSFCEEN DDPQSLPGPW EHPIQQERDK PVSLPAPEMT VKQERLDFEE
     TENKGIHELV DIREPSVEIK MEPAEPEQGL SGPEIVAGVV PATSMEPPEL RSQDLEEEPR
     SIATGEMTEA DVSSGKGDET ALTTVKTEAS PESMLSPSHG SNPIEDPLEA EAQHKFEMSD
     SLKEESGTIF GSQIKDAPGE DEEEDGVSEA ASLEEAKEED QGEGYLSEMD NEPPVSESDD
     GFSIHNATLQ SHTLADSIPS SPASSQFSVC SEDQEAIQAQ KIWKKAIMLV WRAAANHRYA
     NVFLQPVTDD IAPGYHSIVQ RPMDLSTIKK NIENGLIRST AEFQRDIMLM FQNAVMYNSS
     DHDVYHMAVE MQRDVLEQIQ QFLATQLIMQ TSESGISAKS LRGRDSTRKQ DSSEKDSVPM
     GSPAFLLSLF DGGTRGRRCA IEADMKMKK
//