ID A0A452QHQ5_URSAM Unreviewed; 325 AA.
AC A0A452QHQ5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000004602.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000004602.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452QHQ5; -.
DR STRING; 9643.ENSUAMP00000004602; -.
DR Ensembl; ENSUAMT00000005243.1; ENSUAMP00000004602.1; ENSUAMG00000004217.1.
DR GeneTree; ENSGT00940000158350; -.
DR OMA; WVESPQR; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR45872:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 96..274
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 325 AA; 37410 MW; FA4CAF2CF71BAAEA CRC64;
MDTDTEAARL HQSASSSASS LSTRSLENPT PPFTPKMGRR SIESPSLGFC TDALLPHLLE
DDLGQLSDLE PEPDAQNWQH TMGKDAVARL SQREIDRQEV INELFVTEAS HLRTLRVLDL
IFYQWMKKEN LMPREELARL FPNLPELIEI HNSWCEAMRK LREEGPHIRN IGDLMLAWFD
GPGREELQQV AAQFCSYQSI NLGLIKTKQR KESRFQLFMQ EFRDLIMSEM QRLTKYPLLL
ESVLKHMEGG TAEHEKLCWV RDQCWEILKY VNEAPRDVGF LIFQPSFWGT GLLHQYSGNP
VWVESPQRGD GDRCPLRGGM GIGKL
//
