ID A0A452QI34_URSAM Unreviewed; 4062 AA.
AC A0A452QI34;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000004720.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000004720.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSUAMT00000005367.1; ENSUAMP00000004720.1; ENSUAMG00000003684.1.
DR GeneTree; ENSGT00940000155008; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00176; SPEC; 3.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 8.
DR Gene3D; 3.90.1290.10; Plakin repeat; 4.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF23; SHORT STOP, ISOFORM H; 1.
DR Pfam; PF00681; Plectin; 4.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 3.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00250; PLEC; 10.
DR SMART; SM00150; SPEC; 9.
DR SUPFAM; SSF75399; Plakin repeat; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 7.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 562..619
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1138..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1724..1751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1904..1925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1959..1978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1988..2069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2158..2200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2232..2288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 409..443
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 883..917
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1093..1123
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1179..1206
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3391..3425
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3607..3634
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3921..3955
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1911..1925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2232..2247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2252..2288
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4062 AA; 456377 MW; D9E38E23517A5DAA CRC64;
MHSSSYSYRS SDSVFSNTTS TRTSLDSNEN FLSVNCGPTL INSCISFGNE SLDGHRLEML
QQIANRVQRD SVICEDKLIL ARNALQSDSK RLESGVQFQN EAEIAGYILE CENLLRQHVI
DVQILIDGKY YQADQLVQRV AKLRDEIMAL RNECSSVYSK GRMLTTEQTK LMISGITQSL
NSGFAQTLNP SLNSGLTQGL TPSLTPSSVT SGLSSGLTSR LTPSVTPAYT PGFPSGGLVP
SFCSGVETNS LQTLKLMQIR KPLLKSSLLD QNLTEEEVNM KFVQDLLNWV DEMQVQLDRT
EWGSDLPSVE SHLENHKNVH RAIEEFESSL KEAKISEIQM TAPLKLTYAE KLHRLESQYA
KLLNTSRNQE RHLDTLHNFV TRATNELIWL NEKEEEEVAY DWSERNTNIA RKKDYHAELM
RELDQKEENI KSVQEIAEQL LLENHPARLT IEAYRAAMQT QWSWILQLCQ CVEQHIKENT
AYFEFFNDAK EATDYLRNLK DAIQRKYSCD RSSSIHKLED LVQESMEEKE ELLQYKSTVA
SLMGRAKTII QLKPRNPDCP LKTSLPIKAI CDYRQIEITI YKDDECVLAN NSHRAKWKVI
SPTGNEAMVP SVCFTVPPPN KEAVDFANRI EQQYQNVLTL WHESHINMKS VVSWHYLINE
IDRIRASNVA SIKTMLPGEH QQVLSNLQSR FEDFLEDSQE SQVFSGSDIT QLEKEVNVCK
QYYQELLKSA EREEQEESVY NLYISEVRNI RLRLESCEDR LIRQIRTPLE RDDLHESVFR
ITEQEKLKKE LERLKDDLGT ITNKCEEFFS QAATSASVPT LRSELGVVIQ NMNQVYSMSS
TYIEKLKTVN LVLKNTQAAE ALVKLYETKL CEEEAVIADK NNIENLISTL KQWRSEVDEK
REVFHALEDE LQKAKAISDE MFKAYKERDL DFDWHKEKAD QLVERWQNIH VQIDNRLRDL
EGIGKSLKYY RDTYHPLDDW IQQVETTQRK IQENQPENSK TLATQLNQQK MLVSEIEMKQ
SKMDECQKYA EQYSTTVKDY ELQTMTYRAM VDSQQKSPVK RRRMQSSADL IIQEFMDLRT
RYTALVTLMT QYIKFAGDSL KRLEEEEKSL EEEKKEHVEK AKELQKWVSN ISKTLRDGEK
AGKSPFSRQK ISSEEISTKK EQLSEALQTM QLFLAKHGDK MTDEERNELE KQVKSLQESY
NSFFSESLKQ LQDSQTLGDK KLDKVIAGTV DQTTGQVLPV FQAVLRGLID YDTGIRLLET
QLMISGLISP ELRKCFDLQD AKSHGLIDEQ VLCQLKELNQ AKEIISTVSS TTIPVLEALA
QGMISEPMAI RVLEILLSTG FLVIPATGEQ LTLQKAFHQN LVSSALFSKV LEKQNTCKDL
IDPCTAERVS LVDLIQRSIL QDNTGMRLLP VRPQEGGRIT LKCGRNISIL RAAHEGLIDR
ETMFRLLGAQ LLSGGLIDCD SGQRMTVEEA MAAGMIDRDT ANNILTYQVQ TGGIIHSNPA
KRLTVDEAVQ CDLITSSSAL LVLEAQRGYV GLIWPHSGEI FPTSSSLQQD LITNELAYKI
LNGRQKIAAL YIPETSQVIG LDVAKQLGII DNNTASILKS IILPDKMPDL GDLDACKNAR
RWLSFCKFQP STVHDYRQEE DVFVGEEPEA AQSSEQTKKL FLSYLMINSY MDANTGQRLL
LYDGDLNEAV GMLLEGCSAE FEDTPIKACL DALRLPGVFL NNAPSEEKEA SPGSFDTCHY
GEPKHKETPE GRKHAIDDEF NEMGNNVTSS EFCQSENLAN IIATDPKVEN SSIVCVSSSS
SHLTQPGLGA LGTPRQDSEN ILKNRENQSQ VGTNEHAGDC SHSKNIQNFA SDLIANPIVK
SKTRRICDLN EKENEDHMNR DLAIFDYSPR LSALLSHDKL RNDRESFNDA HPTESSGNKC
EDSTLPLSEQ PVLSGQRMGE TFQEQFLGVA AIKIRLQGEP SQQKPVSVGA GPPQVRYRDN
KCISEPYSEH EKLHAASQQK PEDQQTGSRL EEVACALTPQ GDSGNAGTSP VCGTPLPEGP
IGAGDYETSL LDDQPSVTET DTDSEDDFYD TPLFEDDDHD SLLLEGDDRD CLQPEDCAAL
QEETDGAVPP GDVFHDVSRE NDSSMVARGP LVDGLGVRGS PESLQGILIA AENTRFDPGE
RIHSDSVGSH EGSGPLLETM SERESSNSLE GDESDSSTGY RIVERKESFS ALLKFDDTGC
WRGRKEEHIT GQEFKSETEH FDSMQSEESY EDYVCDNNDQ DDDDDYDDDD SDDEEGVEGD
SEESWCQDEA SDMDIQLCAI AVGEKENSQD SQSVNKRILP DKEHNCSSLE NQQSINGLQL
ESTSKSSLVT EGSNPQEDTA EVVGKSAENL LNHELALKDI LLPITKDTES EDTFGSVDIL
HDTNICSTSE VDNDLMNVKV KLIQGPESAD SVKGGDPYFE NVTLQVYSSF DKIICPEPDV
IGKPAEESHL SSIAPVTAKD HQGNERGLIK KKGDQSCILI EEETSVHKMC SGKGEVLGES
LQEDNKDLRL LPSESTRESL DLGNGQFPFP QITDSEEHNQ KGSLEKVTVT LKDEPKNLQT
VVSGSPVQFE NLEEIFDSSV SKVISADVTS DILLSGGDTS TEKESFTDGP EKDSDLFTYL
KHCAKDVKAK DVLKPNEGIL SCVLLASPAR KDHVQFGVDG AKERTALTQE VSSQNEKAQQ
SDVCTEESVS EGQTGIAQLT PERNESTLSI LPLRNVEDRG QNNDFVPPEL CTEGISNGNS
SNPLSTDCLV SEMNNKMEKI EQQWQKEQDL SPGLQEKEVH IPDSSQVFVE DIKAILKSRL
EEGPVNPQEV GESSVCADTK ILIQNLIKRV STSQLANEAS GVPVDFKVGD CSGVSPTSNS
LELKAESRDD PFCIANLKSE LLLDILKQNQ YSQKITGAFE LIKELTQMEY ELEKRGITSK
VPPLQLENIF YKLLADTYSE KVEQVRDWNQ NSSTTSEMVY EKSHILDDLK SKEGNQCSLN
LQNIKDTGLE NSTVCASKLP SDEKLGELCS DIPDHLENIS GSKGMTSGDS SMEQFSMELQ
QCLQHTSKMH EYLALLQDMK PPFDNRESLD NNLEALRNQL KQLETFELGL APIAVILRKD
MKLAEEFLKS LPSDFPRGQL EELRISHQNL QTAFSSLSSV SSERMNHVML AIDSEMSKLA
VSHEEFLQKL ESFSHWISEK SKSVKDIEMV NVQDTEHVKR RLEFLKNVLK DLGCTKVQLE
ATALDVQFFI SECAQDLAPS QSKQLLRLLN TTQKCFLDVQ ESVAAQVEHL ETQLQLEQDL
DDQKIVAERQ QEYKEKLQGI CDLLTQTENR LIGHQEAFVI GDGTVELKKY QSKQEELQKD
MQGNAQALAE IVKNTENFLR ENGEKLSRED KALIEQKLNE AKLKCEQLNL KAEQSKKELD
KVVTTAIKEE TEKVAAAKQL EESKTKIENL LDWLSNVDTD SDRAGVKQRQ VIEQNGTHFQ
EGDGTSVMGE EDEVNGNLLE TDVDGQVGTT EENLNQQYQK VKARHEKIVS QHQAVLMATQ
AAQALLDKQG HHLSPDEKEK LQKNMKELKA HYETALAESE KKMKLTRSLQ EELEKFDADY
GEFEHWLQQS EQELENLEAG ADDLGGLMTK LKRQKSFSED VISHKGDLRY ITISGNRVLE
AAKSCSRRSG GSKAAQDNID TSATYREVQG KLDHATDRFR SLYSKCNVLG NNLKDLVDKY
QHYEDASCGL LSGLQACEVA ASKHLSEPIA VDPKNLQRQL EETKALQGQI SNQQVAVEKL
KKTAEVLLDA RGSLLPAKND IQKTLDDIVG RYDDLSKSVN ERNEKLQITL TRSLSVQDGL
DEMLDWMGSV ESSLKEQGQV PLNSAALQDV ISKNIMLEQD IAGRQSSINA MNEKLKKFME
TTDPSTASSL QAKMKDLSVR FSEASRKHKE KLAKMEELKN KVELFENLSE KLQTFLETKT
QALTEADVPG KDVPELSQYM QRMNTSDQLI HILAALHLAV IVLTVDGLVR IYASLLQKSQ
IPSSPQSLCS LIRNEHHFSR IHFPCIKDDI SIICQNPQRD RL
//
