ID A0A452QIC3_URSAM Unreviewed; 417 AA.
AC A0A452QIC3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Calcium voltage-gated channel auxiliary subunit beta 4 {ECO:0000313|Ensembl:ENSUAMP00000004859.1};
GN Name=CACNB4 {ECO:0000313|Ensembl:ENSUAMP00000004859.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000004859.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000004859.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel beta subunit family.
CC {ECO:0000256|ARBA:ARBA00010836}.
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DR AlphaFoldDB; A0A452QIC3; -.
DR Ensembl; ENSUAMT00000005533.1; ENSUAMP00000004859.1; ENSUAMG00000002586.1.
DR GeneTree; ENSGT00950000182837; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR CDD; cd12043; SH3_CACNB4; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR046937; CAB1-4_N_A-dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR000584; VDCC_L_bsu.
DR PANTHER; PTHR11824; VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT; 1.
DR PANTHER; PTHR11824:SF7; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF12052; VGCC_beta4Aa_N; 1.
DR PRINTS; PR01626; LCACHANNELB.
DR SMART; SM00072; GuKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 59..128
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 133..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 46617 MW; 7C58AC74A69D2724 CRC64;
MYETCQIHQF CQYLCCGSAD SYTSRPSDSD VSLEEDREAI RQEREQQAAI QLERAKSKPV
AFAVKTNVSY CGALDEDVPV PSTAISFDAK DFLHIKEKYN NDWWIGRLVK EGCEIGFIPS
PLRLENIRIQ QEQKRGRFHG GKSSGNSSSS LGEMVSGTFR ATPTSTDGAH SSLRCCAIHA
SGGVSGAVTE GEIERIFELA RSLQLVVLDA DTINHPAQLI KTSLAPIMVH VKVSSPKVLQ
RLIKSRGKSQ SKHLNVQLVA ADKLAQCPPE MFDVILDENQ LEDACEHLGE YLEAYWRATH
TTSSTPMTPL LGRNLGSTAL SPYPTAISGL QSQRMRHSNH STENSPIERR SLMTSDENYH
NERARKSRNR LSSSSQHSRD HYPLVEEDYP DSYQDTYKPH RNRGSPGGYS HDSRHRL
//
