ID A0A452QIL7_URSAM Unreviewed; 1696 AA.
AC A0A452QIL7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000004964.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000004964.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 9643.ENSUAMP00000004964; -.
DR Ensembl; ENSUAMT00000005649.1; ENSUAMP00000004964.1; ENSUAMG00000004242.1.
DR GeneTree; ENSGT00670000098061; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 623..1226
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1326..1638
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 1664..1696
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1616..1637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1696 AA; 192257 MW; 294E8B8D33FC5F7C CRC64;
MPPAASRPAR APGSPGLSLD PVSAPGFRGS ARCLVARAPG SRSQSAVLRV PSASPARSPV
QVATASRRPN AAAPSPFRLS SDICAQFHGS PLRTSILSAG DDSYQKILLA ICEQAAETNN
VYKKHRILKI YHLFVTLLLK DIKSALGGAW AFVLRDVIYT LIHYINRRPS RFVDVSSRSF
SLCCDLLSQV CHTAVTYCKD ALENHLHVIV GTLIPLVDDQ MEVQGQVLDL LKYLVIDNKD
NENLYMTIKL LDPFPDHDVF KDLRITQQKI KYSKGPFSLL EEINHFLSVS AYDALPLTRL
EGLKDLRRQL AQHKDQMAGL MRASQGTGVN DLIVSLLQLC KMAVNHTGER EVLEAVGSCL
GEVGPVDFST IALQHSGDTS STKAPELFED KELQWTFITL TYLNNTLVED CVKVRSAAAT
CLKSILATKT GHSFWEIYKT TPDPMLIYLQ PFRTSKKKVS QIIYKESPLE GLDDMSLWIP
QSENHDIWIK RLTCAFLDSG GTKSEILRLL KPMCEVKTDF CQAVLPYLIH DVLLQDTEES
WRSLLSAHIQ GFFTNCFRHS SPPSRSTTPA NLDSESEHLF RCCVDKKSQR TMLAVVDYMR
RQKRPSLGTV FDDAFWLELN YLEVAKVAQS CAAHFTALLY AEIYADKKSM EDQDKRSAFV
TNRSLTFEEA SQSTAISSLS EKSKEETGIS LQDLLLEIYR SIGEPDSLYG CGGGKLLQPL
TRLRTYEHEA MWGKALVTYD LETAISSSTR QAGIIQALQN LGLCHILSVY LKGLDHENKE
RCVELQELHY QALGLFVLPF LELPLVFSAS RVKEVEELCK GGLESVYSLY PTLSRLQAIG
ELENIGELLA RYVLCTDRQP SEVYAKWRKH SQLLKDSDFS FQEPIMALRT VILEILMEKE
MENSQKECFR DILTKHLVEL SILARTVENT QLPERAMFQI KQYNPATCGV SEWQLEEAQV
FWAKKEQSLA LSILKQMIKK LDASCNDPDL RLIYAECLRV CGTWLAETCL ENPAVIMQTY
LEKAVEVARN YDGESSDELK NGKMKAFLSL ARFSDTQYQR IENYMKSSEF ENKQALLKRA
KEEVGLLREH KIQTNRYTVK VQRELELDEC ALRALKEDRK RFLCKAVENY ISCLLSGEGH
DMWIFRLCSL WLENSGVSEV NGMMKIDGMK IPSYKFLPLM YQLAARMGTK MMGGLGFHEV
LNNLISRIAM DHPHHTLFII LALANANKDE FLTKPEAAGR NRITKNAPKQ SSPLDEDRTE
AANRIIHTIR SRRPQMVRSV EALCDAYIIL ANLDAAQWRT QRITYHLISS VDPTGEYRNL
VTIQSFKAEF RLAGGLNLPK IIDCLGSDGK ERRQLVKGRD DLRQDAVMQQ VFQMCNTLLQ
RNTETRKRKL TICTYKVVPL SQRSGVLEWC TGTVPIGEFL VNNENGAHKR YRPKDFSALH
CQKKMMDVQK KSFEEKYKTF MDVCQKFQPV FRYFCMEKFL DPAVWFEKRL AYTRSVATSS
IVGYILGLGD RHVQNILINE QSAELVHIDL GVAFEQGKIL PTPETVPFRL TRDIVDGMGI
TGVEGVFRRC CEKTMEVMRS SQETLLTIVE VLLYDPLFDW TMNPLKALYL QQRPEDDTEL
HSTPGGEDQE CRRSLSDTDQ SFNKVAERVL MRLQEKLKGV EEGTVLSVGG QVNLLIQQAM
DPKNLSRLFP GWKAWV
//
