ID A0A452QIW6_URSAM Unreviewed; 419 AA.
AC A0A452QIW6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Fuzzy planar cell polarity protein {ECO:0000313|Ensembl:ENSUAMP00000005098.1};
GN Name=FUZ {ECO:0000313|Ensembl:ENSUAMP00000005098.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000005098.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000005098.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the fuzzy family.
CC {ECO:0000256|ARBA:ARBA00008550}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452QIW6; -.
DR STRING; 9643.ENSUAMP00000005098; -.
DR Ensembl; ENSUAMT00000005795.1; ENSUAMP00000005098.1; ENSUAMG00000004591.1.
DR GeneTree; ENSGT00390000010727; -.
DR OMA; LDQYSCS; -.
DR OrthoDB; 3107906at2759; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR GO; GO:0045724; P:positive regulation of cilium assembly; IEA:Ensembl.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd21091; Fuzzy; 1.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR026069; Fuzzy.
DR PANTHER; PTHR13559; INTRACELLULAR TRAFFIC PROTEIN-RELATED; 1.
DR PANTHER; PTHR13559:SF1; PROTEIN FUZZY HOMOLOG; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 11..137
FT /note="FUZ/MON1/HPS1 first Longin"
FT /evidence="ECO:0000259|Pfam:PF19036"
FT DOMAIN 175..269
FT /note="FUZ/MON1/HPS1 second Longin"
FT /evidence="ECO:0000259|Pfam:PF19037"
FT DOMAIN 296..416
FT /note="FUZ/MON1/HPS1 third Longin"
FT /evidence="ECO:0000259|Pfam:PF19038"
SQ SEQUENCE 419 AA; 45614 MW; FA8445FC05276A29 CRC64;
MGEEGTEGTV YLLCLAASSG VPLFCRSSRG GAPARQQLPF SVIGSLNGVH MFGQNLEVQL
SSARTEDTTV VWKSFHDSIT LIVLSSEEGT SELKLERLLQ MVFGAMVLVV GLEELTNIRN
VERLKKELRA SYRLIDSFLG DSELIGDLTQ CVDCVVPPEG SLLQEALSGF AEAAGTAFGS
LVVSGRVVAA TESWWRLGTP EAVLLPWLVG SLPPQAARDY PVYLPHGSPT VPHRLLTLTL
LPGLELCLLC GPRPPLSQLD PQLLDRWWQP VLDPLRACVP LGPRALPAGF PLHMDILGLL
LLHLELKRCL FTVEPSGDQE PSPEQRRRLL RSFYTLATAT HFPPEPGSPE EKVEDVAQKT
QVPRACYLVS GPEEPGAGWR LVALQSGPRR LLLLLSAQSP IHAMRGLATH TLHALTPLL
//
