ID A0A452QKX0_URSAM Unreviewed; 1785 AA.
AC A0A452QKX0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Ankyrin repeat and KH domain containing 1 {ECO:0000313|Ensembl:ENSUAMP00000005907.1};
GN Name=ANKHD1 {ECO:0000313|Ensembl:ENSUAMP00000005907.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000005907.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000005907.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSUAMT00000006694.1; ENSUAMP00000005907.1; ENSUAMG00000004715.1.
DR GeneTree; ENSGT00940000153768; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22503; KH-I_ANKHD1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047374; KH-I_ANKHD1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR23206:SF5; ANKYRIN REPEAT AND KH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23206; MASK PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF00013; KH_1; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 8.
DR PROSITE; PS50088; ANK_REPEAT; 9.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT REPEAT 324..356
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 357..389
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 391..423
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 424..456
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 459..491
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 493..525
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 526..558
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 561..593
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 594..626
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 925..995
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 276..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1491..1529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1542..1610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..136
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 276..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..715
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..731
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1503..1529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1548..1599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1785 AA; 191036 MW; 8154EABAFA0710AA CRC64;
NTFWFWEGGP CVWEGELIFF FSMALFQTFF MCLGTSKQKS SSLQVADQDV LPPFHPYQPL
ECIVEETEGK LNELGQRISA IEKAQLKSLE LIQGEPLNKD KIEELKKNRE EQVQKKKKIL
KELQKVERQL QMKTQQQFTK EYLETKGVFP EGEGDGSLPE DHFSELPQVD TILFKDNDVD
DEQQSPPSAE QIDFVPVQPL SSPQCNFSSD LGSNGTNSLE LQKVSGNHQI IGQPQIAITG
HDQGLLVQEP DGLMVATPAQ TLTDTLDDLI AAVSSRVPSG SNSSSQTTEC LTPEPCSQSP
SNVASQSMPP VYPSVDIDAH TESNHDTALT LACAGGHEEL VSVLIARDAK IEHRDKKGFT
PLILAATAGH VGVVEILLDK GGDIEAQSER TKDTPLSLAC SGGRQEVVDL LLARGANKEH
RNVSDYTPLS LAASGGYVNI IKILLNAGAE INSRTGSKLG ISPLMLAAMN GHVPAVKLLL
DMGSDINAQI ETNRNTALTL ACFQGRAEVV SLLLDRKANV EHRAKTGLTP LMEAASGGYA
EVGRVLLDKG ADVNAPPVPS SRDTALTIAA DKGHYKFCEL LINRGAHIDV RNKKGNTPLW
LASNGGHFDV VQLLVQAGAD VDAADNRKIT PLMSAFRKGH VKVVQYLVKE VNQFPSDIEC
MRYIATITDK SREESRKQAL AAKREKRKEK RKKKKEEQKR KQEEDEENKP KENSELPEDE
DEEENDEDEV PIEPPSATTT TTIGISATSA TFTNVFGKKR ANVVTTPSTN RKNKKNKTKE
TPPTAHLILP EQHISLAQQK ADKNKINGEP RGGGTGGNSD SDNLDSTDCN SESSSGGKSQ
ELNFTVDVNS SSDRRYPSLL LHSQEEKTST ATSKTQTRLE GETNTNSLST SYKSVPLPLS
SPNIKLNLTS PKRGQKREEG WKEVVRRSKK LSVPASVVSR IMGRGGCNIT AIQDVTGAHI
DVDKQKDKNG ERMITIRGGT ESTRYAVQLI NALIQDPAKE LEDLIPKNHI RTPASTKSIH
ANFSSGVGTT AASSKNAFPL GAPTLVTSQA TTLSTFQPTN KLNKNVPANV RSSFPVSLPL
AYPHPHFALL AAQTMQQIRH PRLPMAQFGG TFSPSPNTWG PFPVRPVNPG NTNSSPKHNS
AGRLPNQNGT VLPSESAGLA TASCPITVSS VVAASQQLCV TNTRTPSSVR KQLFACVPKT
SPPATVISSV TSTCSSLPSV SSAPITSGQV PTTFLPASTP QGQLSSQKME SFSAMPPPKE
KVSTQDQALA NLCTPSSAAN SCSSSASNTP GAPETHPSSS PAPPSGNTQE EAQPAGVSDL
SPMSMPFASN SEPAPLTLAS PRLVAADNQD TSNLPQLAVP APRVSHRMQP RGSFYSVVPN
ATIHQDPQSI FVTNPVPLTP PQGPPAAVQL SSAMNIMNGS QMHINPANKS LPPTFGPATL
FNHFSSLFDS SQVPANQGWG DGPLSSRVAA DASFTVQSAF LGNSVLGHLE NVHPDNSKAP
GFRPPSQRVS TSPHFLESSS PSSSSAPLTS FSGIPGTRVF LQGPAPVGTP SFNRQHFSPH
PWTSASNSCD SPIPSVSSGS SSPLSATSAP PTLGQPKGGS ASQDRKIPPP IGTERLARIR
QGGSVAQAPV GTSFVAPVGH SGIWSFGVNA MSEGLSGWSQ SVIGNHPMHQ QLSDPSTFSQ
HQPMERDDSG MVAPSNIFHQ PMASSFLDFS KGLPISMYGG TIIPSHPQLA DVPGGPLFNG
LHNPDPAWNP MIKVIQNSTE CTDAQQIWPG TWAPHIGNMH LKYVN
//
