ID A0A452QL71_URSAM Unreviewed; 412 AA.
AC A0A452QL71;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Receptor associated protein of the synapse {ECO:0000313|Ensembl:ENSUAMP00000006025.1};
GN Name=RAPSN {ECO:0000313|Ensembl:ENSUAMP00000006025.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000006025.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000006025.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAPsyn family.
CC {ECO:0000256|ARBA:ARBA00007295}.
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DR AlphaFoldDB; A0A452QL71; -.
DR STRING; 9643.ENSUAMP00000006025; -.
DR Ensembl; ENSUAMT00000006821.1; ENSUAMP00000006025.1; ENSUAMG00000005314.1.
DR GeneTree; ENSGT00390000016785; -.
DR OMA; ALRCSHI; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:InterPro.
DR GO; GO:0033130; F:acetylcholine receptor binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR GO; GO:0007271; P:synaptic transmission, cholinergic; IEA:Ensembl.
DR CDD; cd16478; RING-H2_Rapsyn; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001237; Postsynaptic.
DR InterPro; IPR018293; Postsynaptic_CS.
DR InterPro; IPR019568; Rapsyn_myristoylation/link_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46574; 43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE; 1.
DR PANTHER; PTHR46574:SF1; 43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE; 1.
DR Pfam; PF10579; Rapsyn_N; 1.
DR Pfam; PF17874; TPR_MalT; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR PRINTS; PR00217; POSTSYNAPTIC.
DR SMART; SM00184; RING; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS00405; 43_KD_POSTSYNAPTIC; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 123..156
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 363..403
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT COILED 298..329
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 412 AA; 46279 MW; 2126F65EF73B21E9 CRC64;
MGQDQTKQQI EKGLQLYQSN QTEKALHVWT KVLEKSADLV GRFRVLGCLV TAHSEMGRYK
EMLKFAVVQI DTARELEDAD FLLESYLNLA RSNEKLCEFH KTISYCKTCL GLPGTRAGAQ
LGGQVSLSMG NAFLGLSLFQ KALESFEKAL RYAHNNDDAM LECRVCCSLG SFYAQVKDYE
KALFFPCKAA ELVSDYGKGW SLKYRAMSQY HMAVAYRLLG HLGSAMECCE ESMKIALQHG
DRPLQALCLL CFADIHRSRG DLETAFPRYD SAMSIMTEIG NRLGQVQVLL GVAKCWIARK
ALDKALEAIE KAQDLAEEVG NKLSQLKLHC LSEGVYRSKG LQRELRAHVV RFHECVEETE
LYCGLCGESI GERNSRLQAL PCSHIFHLRC LHNNGTRSCP NCRRSSMKPG FV
//
