ID   A0A452QLV0_URSAM        Unreviewed;      1004 AA.
AC   A0A452QLV0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Formin like 3 {ECO:0000313|Ensembl:ENSUAMP00000006271.1};
GN   Name=FMNL3 {ECO:0000313|Ensembl:ENSUAMP00000006271.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000006271.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000006271.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the formin homology family.
CC       {ECO:0000256|ARBA:ARBA00023449}.
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DR   AlphaFoldDB; A0A452QLV0; -.
DR   Ensembl; ENSUAMT00000007093.1; ENSUAMP00000006271.1; ENSUAMG00000004034.1.
DR   GeneTree; ENSGT00940000159962; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR010472; FH3_dom.
DR   InterPro; IPR043592; FMNL_animal.
DR   InterPro; IPR014768; GBD/FH3_dom.
DR   InterPro; IPR010473; GTPase-bd.
DR   PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR   PANTHER; PTHR45857:SF3; FORMIN-LIKE PROTEIN 3; 1.
DR   Pfam; PF06367; Drf_FH3; 1.
DR   Pfam; PF06371; Drf_GBD; 2.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM01139; Drf_FH3; 1.
DR   SMART; SM01140; Drf_GBD; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51232; GBD_FH3; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          1..452
FT                   /note="GBD/FH3"
FT                   /evidence="ECO:0000259|PROSITE:PS51232"
FT   DOMAIN          540..930
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   REGION          481..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          371..444
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          904..933
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        485..515
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1004 AA;  114961 MW;  3D98E2E7843B8503 CRC64;
     FPCDGKESSM NLPPDKARLL RQYDNEKKWD LICDQERFQV KNPPHTYIQK LQSFLDPSVT
     RKKFRRRVQE STKVLRELEI SLRTNHIGWV REFLNDENKG LDVLVDYLSF AQCSVMFDFE
     GLESGDDGAF DKLRSWSRSI EDLQPPSALS APFTNSLARS ARQSVLRYVC SCSARLPFTS
     SPLFPRYSTL PGRRALKNSR LVSQKDDVHV CILCLRAIMN YQYGFNLVMS HPHAVNEIAL
     SLNNKNPRTK ALVLELLAAV CLVRGGHEII LAAFDNFKEV CKELHRFEKL MEYFRNEDSN
     IDFMVACMQF INIVVHSVED MNFRVHLQYE FTKLGLEEFL HTESEKLQVQ IQAYLDNVFD
     VGGLLEDAET KNVALEKVEE LEEHVSHLTE KLLDLENENM MRVAELEKQL LQREKELESV
     KETYENTSHQ VHTLRRLIKE KEEAFQRRCH LEPGARGLES VGSEALARIG PAELSEGMLP
     SDLDLLAPAP PPEEALPLPP PPAPPLPPPP PPLPGEEDRG HPETPLRRLT DLPSKLAIRI
     KKPIKTKFRL PVFNWTALKP NQISGTVFSE LDDEKILEDL DLDKFEELFK TKAQGPALDL
     ICSKNKTAQK AASKVTLLEA NRAKNLAITL RKAGRSAEEI CRAIHTFDLQ TLPVDFVECL
     MRFLPTEAEV KLLRQYERER QPLDELAAED RFMLLFSKVE RLTQRMAGMA FLGNFQDNLQ
     MLTPQLNAII AASASVKSSQ KLKQMLEIIL ALGNYMNSSK RGAVYGFKLQ SLDLLLDTKS
     TDRKMTLLHF IALTVKEKYP DLANFWHELH FVEKAAAVSL ENVLLDVKEL GRGMELIRRE
     CGIHDNSVLR NFLSTNEGKL DKLQRDAKTA EEAYNAVVRY FGESPKTTPP SVFFPVFVRF
     IRSYKEAEQE NEARKKQEEV MREKQLAQEA KKLDAKTPSQ RNKWQQQELI AELRRRQAKE
     HRPVYEGKDG TIEDIITVLK SVPFTARTAK RGSRFFSPSP PFHN
//