ID A0A452QN90_URSAM Unreviewed; 1554 AA.
AC A0A452QN90;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Chromodomain helicase DNA binding protein 8 {ECO:0000313|Ensembl:ENSUAMP00000006793.1};
GN Name=CHD8 {ECO:0000313|Ensembl:ENSUAMP00000006793.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000006793.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000006793.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR Ensembl; ENSUAMT00000007685.1; ENSUAMP00000006793.1; ENSUAMG00000004198.1.
DR GeneTree; ENSGT00940000153649; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.5.120; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR006576; BRK_domain.
DR InterPro; IPR037259; BRK_sf.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR46850:SF2; -; 1.
DR PANTHER; PTHR46850; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR Pfam; PF07533; BRK; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00592; BRK; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF160481; BRK domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 65..239
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 379..530
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1203..1279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1245..1264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1554 AA; 179388 MW; 025914081A374F46 CRC64;
STWELKEDVD EGKIREFKRI QSRHPELKRV NRPQASAWKK LELSHEYKNR NQLREYQLEG
VNWLLFNWYN RQNCILADEM GLGKTIQSIA FLQEVYNVGI HGPFLVIAPL STITNWEREF
NTWTEMNTIV YHGSLASRQM IQQYEMYCKD SRGRLIPGAY KFDALITTFE MILSDCPELR
EIEWRCVIID EAHRLKNRNC KLLDSLKHMD LEHKVLLTGT PLQNTVEELF SLLHFLEPSQ
FPSESEFLKD FGDLKTEEQV QKLQAILKPM MLRRLKEDVE KNLAPKQETI IEVELTNIQK
KYYRAILEKN FSFLSKGAGH TNMPNLLNTM MELRKCCNHP YLINGAEEKI LTEFREACHI
IPHDFHLQAM VRSAGKLVLI DKLLPKLKAG GHKVLIFSQM VRCLDILEDY LIQRRYLYER
IDGRVRGNLR QAAIDRFSKP DSDRFVFLLC TRAGGLGINL TAADTCIIFD SDWNPQNDLQ
AQARCHRIGQ SKAVKVYRLI TRNSYEREMF DKASLKLGLD KAVLQSMSGR DGNITGIQQF
SKKEIEDLLR KGAYAAIMEE DDEGSKFCEE DIDQILLRRT TTITIESEGK GSTFAKASFV
ASENRTDISL DDPNFWQKWA KKADLDMDLL NSKNNLVIDT PRVRKQTRHF STLKDDDLVE
FSDLESEDDE RPRSRRHDRH HTYGRTDCFR VEKHLLVYGW GRWRDILSHG RFKRRMTERD
VETICRAILV YCLLHYRGDE NIKGFIWDLI SPAENGKTKE LQNHSGLSIP VPRGRKGKKV
KSQSTFDIHK ADWIRKYNPD TLFQDESYKK HLKHQCNKVL LRVRMLYYLR QEVIGDQAEK
VLGGAIASEI DIWFPVVDQL EVPTTWWDSE ADKSLLIGVF KHGYEKYNTM RADPALCFLE
KAGRPDDKAI AAEHRVLDNF SDIVTQQPGH LFWPPGSALT ARLRRLVTAY QRSYKREQMK
IEAAERGDRR RRRCEAAFKL KEIARREKQQ RWTRREQTDF YRVVSTFGVE YDPDTMQFHW
DRFRTFARLD KKTDESLTKY FHGFVAMCRQ VCRLPPAAGD EPPDPNLFIE PITEERASRT
LYRIELLRRL REQVLCHPLL EDRLALCQPP GPELPKWWEP VRHDGELLRG AARHGVSQTD
CNIMQDPDFS FLAARMNYMQ NHQAGAPAPS LSRCSTPLLH QQYTSRTASP LLTLKLEHEV
VARSRPTPQD YEMRVAPPDT TPLVSRNVPP VKLEDEDDSD SELDLSKLSP SSSSSSSSSS
SSSSTDESED EKEEKLTGTQ ALKPVLISFP PTQDRILINR IDLVCQAVLS GKWPSSRRSQ
EMVTGGILGP GNHLLDSPSL TPGEYGDSPV PTPRSSSAAS MAEEEVSAVT TAAAQFTKLR
RGMDEKEFTE GLKLTFQKHK LMANGVMGDG HPLFHKKKGN RKKLVEKILE LFYGYHWLCS
PSLPAPKKSM CSWGWILGLQ LEVECMEEPN HLDVDLETRI PVINKVDGTL LVGEDAPRRA
ELEMWLQGHP EFAVDPRFLY MEDRRKQKWQ RCKKNNKAEL NCLGMEPVPT ALPL
//
