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Database: UniProt
Entry: A0A452QNE9_URSAM
LinkDB: A0A452QNE9_URSAM
Original site: A0A452QNE9_URSAM 
ID   A0A452QNE9_URSAM        Unreviewed;       406 AA.
AC   A0A452QNE9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Cyclic GMP-AMP synthase {ECO:0000313|Ensembl:ENSUAMP00000006934.1};
GN   Name=CGAS {ECO:0000313|Ensembl:ENSUAMP00000006934.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000006934.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000006934.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A452QNE9; -.
DR   STRING; 9643.ENSUAMP00000006934; -.
DR   Ensembl; ENSUAMT00000007862.1; ENSUAMP00000006934.1; ENSUAMG00000006074.1.
DR   GeneTree; ENSGT01050000244827; -.
DR   OMA; CCENKEA; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR   GO; GO:0061501; F:2',3'-cyclic GMP-AMP synthase activity; IEA:Ensembl.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0140693; F:molecular condensate scaffold activity; IEA:Ensembl.
DR   GO; GO:0031491; F:nucleosome binding; IEA:Ensembl.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0019933; P:cAMP-mediated signaling; IEA:Ensembl.
DR   GO; GO:0140896; P:cGAS/STING signaling pathway; IEA:Ensembl.
DR   GO; GO:0019934; P:cGMP-mediated signaling; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR   GO; GO:0160049; P:negative regulation of cGAS/STING signaling pathway; IEA:Ensembl.
DR   GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
DR   GO; GO:0038001; P:paracrine signaling; IEA:Ensembl.
DR   GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
DR   GO; GO:0032481; P:positive regulation of type I interferon production; IEA:Ensembl.
DR   Gene3D; 1.10.1410.40; -; 1.
DR   Gene3D; 3.30.460.90; -; 1.
DR   InterPro; IPR024810; Mab-21-like.
DR   InterPro; IPR046903; Mab-21-like_nuc_Trfase.
DR   PANTHER; PTHR10656; CELL FATE DETERMINING PROTEIN MAB21-RELATED; 1.
DR   PANTHER; PTHR10656:SF35; CYCLIC GMP-AMP SYNTHASE; 1.
DR   Pfam; PF03281; Mab-21; 1.
DR   SMART; SM01265; Mab-21; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          212..388
FT                   /note="Mab-21-like nucleotidyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF03281"
FT   REGION          1..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  44721 MW;  FAF570D96C796B26 CRC64;
     MDPRRGKATR TTSRAGAATP RVLAQGVKGP RADPSEHPAA LGAAGPKAQK CGPVGASGSR
     RKKSAPSSPE RPQVRARTTR AKRAPLGAED VVEGLAVPAE KMAPPAAPGP PLPRTGSRRE
     RGARAAGEQR ALPEPTEVSG LGPLVPASSL RRRGAAPGAW KPRAVLEKLR LRRQEISEAA
     EVVNRVVDHL LRRLQSCESE FEGVSLLRTG SYYEHVKISA PNEFDIMFKL EVPRIQLEEY
     CNSGAYYFVK FKRNPKGNPL SQFLEDEILS ASKMLLKFRK IIKEEIKNIQ DTDVIMEKKK
     RGSPAVTLLI RKPKEISVDI ILALESKSSW PASTQEGLPI SQWLGTKVKT SLRRQPFYLV
     PKHAKEGNGF QEETWRLSFS HIEKDLLKSH GHSKTCCETD GVKCCR
//
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