ID A0A452QNN0_URSAM Unreviewed; 1011 AA.
AC A0A452QNN0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Integrin subunit alpha 2b {ECO:0000313|Ensembl:ENSUAMP00000006957.1};
GN Name=ITGA2B {ECO:0000313|Ensembl:ENSUAMP00000006957.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000006957.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000006957.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452QNN0; -.
DR Ensembl; ENSUAMT00000007887.1; ENSUAMP00000006957.1; ENSUAMG00000004666.1.
DR GeneTree; ENSGT00940000160724; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF73; INTEGRIN ALPHA-IIB; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 32..1011
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5018809408"
FT TRANSMEM 977..999
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 38..96
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 287..352
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 354..413
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 416..477
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 462..613
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 614..754
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 760..967
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 835..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..860
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1011 AA; 109836 MW; A76ECE38C3525405 CRC64;
MARAVCPLHA LWLLEWVQLL LGPGAIPAAW ALNLDPVQLT LYTGPNGSHF GFALDFYKDN
HGRVAIVVGA PRTLGPSQEE TGGVFLCPWK AEGSQCTLLP FDLNDETRHV GSHTFQTFKS
RQGLGASVVS WNDNIVACAP WQHWNALEKT EEAEKTPVGG CFVAQLQNGH RAEYSPCRAN
TMSQVYVKNG FNDRRYCEAG FSSAVTQAGE LVLGAPGGYF FLGTCPIVSS YRPGTLLWHV
PFQSFTFDYS KPEYYDGYRG NPGTSLLGLP ALSPPTPPVR SCPCGSAPTP TRGPTPMASY
FGHSVTVTDV NGDGRHDLLV GAPLYMESRA DRKLAEVGRV YLFLQPRGHH VLGAPSLLLT
GTQLYGRFGS AIAPLGDLDR DGYNDVAVAA PYGGPSGRGQ VLVFLGQSEG LSSRPSQILD
SPFPAGSGFG FSLRGATDID DNGYPDLLVG AYGANKVAVY RAQPVVMASV QLLVQDSLNP
AVKNCVLPQT QTLVSCFNIQ MCVGATGHNI PQQLPLSAEL QLDRQKPRQG RRVLLLNSQL
AGTTLHLDLG GRQSPICHTT VAFLRDEADF RDKLSPIVLS FNVSLQPRKD GVAPGLVLHG
DTHVQEQTRI ILDCGEDDLC VPQLQLTASV AGSPLLIGAD NVLELQMDAA NEGEGAYEAE
LAVHLPPGAH YMRAVSNVEG FERLICNQKK ENETKMVLCE LGNPMKRNAR IGITMLVSVE
NLEEAGEHVS FWLQTRSKNS QNPNSEAVLL DVPVRAEAHV ELRGNSFPAS LVVVAEEDNR
ENSSDIWGPK VEHTYELHNN GPSTISGIHL SLCLPGQSQR SDLLYILDIE PQGGLQCSPQ
PTPNPDKMNW RLPTPSPSPT SPGHHKRERR QASLPGSNQP AGLQDPILLS CDSGPHTVVQ
CELREMARGQ RAMVRVLAFL QLPSLQQRPL DQFVLQSQAW FNVSSLPYAV PALSLPSGET
QVQTRLLRAL EERDIPIWWV LVGVLGGLLL LMLLVLAMWK VRHEGESGVP R
//
