ID A0A452QPF4_URSAM Unreviewed; 1212 AA.
AC A0A452QPF4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=mitogen-activated protein kinase kinase kinase {ECO:0000256|ARBA:ARBA00012406};
DE EC=2.7.11.25 {ECO:0000256|ARBA:ARBA00012406};
GN Name=MAP3K5 {ECO:0000313|Ensembl:ENSUAMP00000007352.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000007352.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000007352.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. MAP kinase kinase kinase subfamily.
CC {ECO:0000256|ARBA:ARBA00006529}.
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DR AlphaFoldDB; A0A452QPF4; -.
DR STRING; 9643.ENSUAMP00000007352; -.
DR Ensembl; ENSUAMT00000008325.1; ENSUAMP00000007352.1; ENSUAMG00000006263.1.
DR GeneTree; ENSGT00940000159155; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:1990604; C:IRE1-TRAF2-ASK1 complex; IEA:Ensembl.
DR GO; GO:1902911; C:protein kinase complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004706; F:JUN kinase kinase kinase activity; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:Ensembl.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
DR GO; GO:0007254; P:JNK cascade; IEA:Ensembl.
DR GO; GO:0036480; P:neuron intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR CDD; cd06624; STKc_ASK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046873; HisK-N-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR043969; MAP3K_PH.
DR InterPro; IPR025136; MAP3K_TRAF-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11584:SF332; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5; 1.
DR PANTHER; PTHR11584; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF19039; ASK_PH; 1.
DR Pfam; PF20302; HisK-N-like; 1.
DR Pfam; PF13281; MAP3K_TRAF_bd; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT DOMAIN 518..776
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1019..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1083..1117
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 547
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1212 AA; 137856 MW; 90A66A481E13F4A0 CRC64;
SCWVSGTGCP YQKLTILSRY FNMFEFSGEL TPHPSWRLLF LQMCTGNYTF VPYMITPHNK
VYCCDSSFMK GLTELMQPNF ELLLGPICLP LVDRFIQLLK VAQASSSQYF RESILNDIRK
ARNLYTGKEL AAELARIRQR VDNIEVLTAD IVINLLLSYR DIQDYDSIVK LVETLEKLPT
FDLASHHHVK FHYAFALNRR NLPGDRAKAL DVMIPLVQSE GQVASDMYCL VGRIYKDMFL
DSNFLDTESR DHGASWFKKA FESEPSLQSG INYAVLLLAA GHQFESSFEL RKVGVKLSSL
LGKKGNLEKL QSYWEVGFFL GASVLANDHM RVIQASEKLF KLKTPAWYLK SIVETILIYK
HFVKLTTEQP VAKQELVDFW MDFLVEATKT DVTVVRFPVL ILEPTKIYQP SYLSINNEVE
EKTISIWHVL PDDKKGIHEW NFSASSVRGV SISKFEERCC FLYVLHNSDD FQIYFCTELH
CKKFFEMVNT ITEEKGRSTE EGDCESDSLE YDYEYDENGD RVVLGKGTYG IVYAGRDLSN
QVRIAIKEIP ERDSRYSQPL HEEIALHKHL KHKNIVQYLG SFSENGFIKI FMEQVPGGSL
SALLRSKWGP LKDNEQTIGF YTKQILEGLK YLHDNQIVHR DIKGDNVLIN TYSGVLKISD
FGTSKRLAGI NPCTETFTGT LQYMAPEIID KGPRGYGKAA DIWSLGCTII EMATGKPPFY
ELGEPQAAMF KVGMFKVHPE IPESMSAEAK AFILKCFEPD PDKRACANDL LIDEFLKVSS
KKKKTQPKLS ALSAGSNEYL RSISLPVPVL VEDTSSSSEY GSVSPDTELK VDPFSFKTRA
KSCGERDVKG IRTLFLGIPD ENFEDHSAPP SPEEKDSGFF MLRKDSERRA TLHRILTEDQ
DKVVRNLMES LAQGAEEPKL KWEHITTLIA SLREFVRTTD RKIIATTLSK LKLELDFDSH
GISQVQVVLF GFQDAVNKVL RNHNIKPHWM FALDSIIRKA VQTAITILVP ELRPHFSLAS
ESDTADQEDL DAEDDHEERP SNQTIRRPHA VIEDAVATSG VSTLSSTVSH DSQNAHRSLN
VQLGRMKIET NRLLEELVQK EKELQALLHQ AIEEKDQEIK HLKLKSQPID IPGLPECPRD
SPGTNTEESE LTEWLREKGA DEDTISRFLA EDYSLEDVLF YVTRDDLKCL RLRGGTLCTL
WKAITDFRDT QT
//
