ID A0A452QPF8_URSAM Unreviewed; 1169 AA.
AC A0A452QPF8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=mitogen-activated protein kinase kinase kinase {ECO:0000256|ARBA:ARBA00012406};
DE EC=2.7.11.25 {ECO:0000256|ARBA:ARBA00012406};
GN Name=MAP3K5 {ECO:0000313|Ensembl:ENSUAMP00000007358.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000007358.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000007358.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. MAP kinase kinase kinase subfamily.
CC {ECO:0000256|ARBA:ARBA00006529}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452QPF8; -.
DR Ensembl; ENSUAMT00000008332.1; ENSUAMP00000007358.1; ENSUAMG00000006263.1.
DR GeneTree; ENSGT00940000159155; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06624; STKc_ASK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046873; HisK-N-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR043969; MAP3K_PH.
DR InterPro; IPR025136; MAP3K_TRAF-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR11584:SF332; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5; 1.
DR PANTHER; PTHR11584; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF19039; ASK_PH; 1.
DR Pfam; PF20302; HisK-N-like; 1.
DR Pfam; PF13281; MAP3K_TRAF_bd; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT DOMAIN 475..733
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 976..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1040..1074
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 504
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1169 AA; 132823 MW; F65361F2B20F3BA7 CRC64;
MCTGNYTFVP YMITPHNKVY CCDSSFMKGL TELMQPNFEL LLGPICLPLV DRFIQLLKVA
QASSSQYFRE SILNDIRKAR NLYTGKELAA ELARIRQRVD NIEVLTADIV INLLLSYRDI
QDYDSIVKLV ETLEKLPTFD LASHHHVKFH YAFALNRRNL PGDRAKALDV MIPLVQSEGQ
VASDMYCLVG RIYKDMFLDS NFLDTESRDH GASWFKKAFE SEPSLQSGIN YAVLLLAAGH
QFESSFELRK VGVKLSSLLG KKGNLEKLQS YWEVGFFLGA SVLANDHMRV IQASEKLFKL
KTPAWYLKSI VETILIYKHF VKLTTEQPVA KQELVDFWMD FLVEATKTDV TVVRFPVLIL
EPTKIYQPSY LSINNEVEEK TISIWHVLPD DKKGIHEWNF SASSVRGVSI SKFEERCCFL
YVLHNSDDFQ IYFCTKKKIM FFEMVNTITE EKGRSTEEGD CESDSLEYDY EYDENGDRVV
LGKGTYGIVY AGRDLSNQVR IAIKEIPERD SRYSQPLHEE IALHKHLKHK NIVQYLGSFS
ENGFIKIFME QVPGGSLSAL LRSKWGPLKD NEQTIGFYTK QILEGLKYLH DNQIVHRDIK
GDNVLINTYS GVLKISDFGT SKRLAGINPC TETFTGTLQY MAPEIIDKGP RGYGKAADIW
SLGCTIIEMA TGKPPFYELG EPQAAMFKVG MFKVHPEIPE SMSAEAKAFI LKCFEPDPDK
RACANDLLID EFLKVSSKKK KTQPKLSALS AGSNEYLRSI SLPVPVLVED TSSSSEYGSV
SPDTELKVDP FSFKTRAKSC GERDVKGIRT LFLGIPDENF EDHSAPPSPE EKDSGFFMLR
KDSERRATLH RILTEDQDKV VRNLMESLAQ GAEEPKLKWE HITTLIASLR EFVRTTDRKI
IATTLSKLKL ELDFDSHGIS QVQVVLFGFQ DAVNKVLRNH NIKPHWMFAL DSIIRKAVQT
AITILVPELR PHFSLASESD TADQEDLDAE DDHEERPSNQ TIRRPHAVIE DAVATSGVST
LSSTVSHDSQ NAHRSLNVQL GRMKIETNRL LEELVQKEKE LQALLHQAIE EKDQEIKHLK
LKSQPIDIPG LPECPRDSPG TNTEESELTE WLREKGADED TISRFLAEDY SLEDVLFYVT
RDDLKCLRLR GGTLCTLWKA ITDFRDTQT
//
