ID A0A452QPN1_URSAM Unreviewed; 631 AA.
AC A0A452QPN1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=L3MBTL histone methyl-lysine binding protein 4 {ECO:0000313|Ensembl:ENSUAMP00000007455.1};
GN Name=L3MBTL4 {ECO:0000313|Ensembl:ENSUAMP00000007455.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000007455.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000007455.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A452QPN1; -.
DR STRING; 9643.ENSUAMP00000007455; -.
DR Ensembl; ENSUAMT00000008433.1; ENSUAMP00000007455.1; ENSUAMG00000006450.1.
DR GeneTree; ENSGT00940000158264; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20136; MBT_L3MBTL4_rpt2; 1.
DR CDD; cd09582; SAM_Scm-like-3MBT3_4; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 4.10.320.30; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR002515; Znf_C2H2C.
DR PANTHER; PTHR12247:SF78; LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 4; 1.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR Pfam; PF02820; MBT; 3.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF01530; zf-C2HC; 1.
DR SMART; SM00561; MBT; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51079; MBT; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51802; ZF_CCHHC; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT REPEAT 69..169
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 177..277
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 286..381
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 551..615
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
SQ SEQUENCE 631 AA; 72109 MW; 26E81D2A723346A1 CRC64;
MTHFTCYHPF TFLGGLPPGR GWGYIHRLVL KQEKLHMDWS DDFTQCSWKV RDKSLFSFPV
PSVAAQEAWS WEQYLTEQKA AAAPVELFSK DQSFPEHENG FQVGMRLEGI DPRHPSVFCV
LSVAEVCGYR LRLHFDGYLS CYDFWTNAGS PDIHPVGWCE KTKHELHIPK GYRKDKFVWM
DYLKACKLQN APKKLFRNRS SNGPMPKEFQ VGMKLEAVDR KNPSLVCVAT IADIVEDRLL
VHFDNWDDSY DYWCDVNSPY VQPVGWCQEN GRTLIAPQGY PDPENFSWTD YLEATQTNAV
PAKVFKMRTP HGFLPSMRLE AVDRRNPRLI RVATVIDVDD QRVKVHFDGW DHKYDYWMDA
DSPDIHPIGW CDITGHPLEI PYRANDVKIL PGQAVCPTPG CRGIGHIRGP RYSGHHSAFG
CPYSDMNLKK EATLHDRLRE QTQANLESDS SHSKSKNLCS LNFSGKPEKV NSQPRLVQQA
QCLKIKGKED IDLDNLFREY SAEQTQQALH QSVFMSSVSA HPFRDLPLGR EQHCKLLPGV
ANIQAGEVAR WTVDEVAEFV RSLLGCEEHA KCFKKEQIDG KAFLLLTQTD IVKVMKIKLG
PALKIYNSIL MFRNSRDLTE EDSLSGQEAR G
//
