ID A0A452QQE6_URSAM Unreviewed; 1400 AA.
AC A0A452QQE6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Patched 1 {ECO:0000313|Ensembl:ENSUAMP00000007759.1};
GN Name=PTCH1 {ECO:0000313|Ensembl:ENSUAMP00000007759.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000007759.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000007759.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSUAMT00000008759.1; ENSUAMP00000007759.1; ENSUAMG00000004488.1.
DR GeneTree; ENSGT00940000159011; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 446..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 699..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 736..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1002..1024
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1031..1057
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1069..1089
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1101..1126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 440..546
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 15..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1155
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1249
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1250..1274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1400 AA; 156069 MW; AEA1A1D4B9C81971 CRC64;
XXXXXXXXXX XXXXXXGGSC SGAPGRPAGG GRRRRTGGLR RNAVLDRDYL HRPSYCDAAF
ALEQISKGKA TGRKAPLWLR AKFQRLLFKL GCYIQKNCGK FLVVGLLIFG AFAVGLKAAN
LETNVEELWV EVGGRVSREL NYTRQKIGEE AMFNPQLMIQ TPKEEGANVL TTEALRQHLD
SALQASRVHV YMYNRQWKLE HLCYKSGELI TETGYMDQII EYLYPCLIIT PLDCFWEGAK
LQSGTAYLLG KPPLQWTNFD PLEFLEELKK INYQVDSWEE MLNKAEVGHG YMDRPCLNPA
DPDCPATAPN KNATKPLDVA LVLSGGCHGL SRKYMHWQEE LIVGGTVKNS TGKLVSAHAL
QTMFQLMTPK QMYEHFKGYE YVSHINWNED KAAAILEAWQ RTYVEVVHQS VTPNSTQQVL
SFTTTTLDDI LKSFSDVSVI RVASGYLLMV LPFLALGVGV DDVFLLAHAF SETGQNKRIP
FEDRTGECLK RTGASVALTS ISNVTAFFMA ALIPIPALRA FSLQAAVVVV FNFAMVLLIF
PAILSMDLYR REDRRLDIFC CFTSPCVSRV IQVEPQAYTE THDNTRYSPP PPYSSHSFAH
ETQITMQSTV QLRTEYDPHT HVYYTTAEPR SEISVQPVTM TQDTLSCQSP ESTSSTRDLL
SQFSDSSLHC LEPPCTKWTL SSFAEKHYAP FLLKPKAKVV VIFLFLGLLG VSLYGTTRVR
DGLDLTDIVP RETREYDFIA AQFKYFSFYN MYIVTQKADY PNIQHLLYDL HKSFSNVKYV
MLEENKQLPK MWLHYFRDWL QGLQDAFDSD WETGKIMPNN YKNGSDDGVL AYKLLVQTGS
RDKPIDISQL TKRRLVDADG IINPSAFYIY LTAWVSNDPV AYAASQANIR PHRPEWVHDK
ADYMPETRLR IPAAEPIEYA QFPFYLNGLR DTSDFVEAIE KVRTICNNYT SLGLSSYPNG
YPFLFWEQYI GLRHWLLLSI SVVLACTFLV CAVFLLNPWT AGIIVTVLAL MTVELFGMMG
LIGIKLSAVP VVILIASVGI GVEFTVHVAL AFLTAIGDKN RRAVLALEHM FAPVLDGAVS
TLLGVLMLAG SEFDFIVRYF FAVLAILTIL GVLNGLVLLP VLLSFFGPYP EVSPANGLNR
LPTPSPEPPP SVVRFAVPPG HANNGSDSSD SEYSSQTTVS GISEELRHYE AQQGTGGPAH
QVIVEATENP VFARSTVVHP EARHHPPSNP RQQPPPDSES LPPGRPGQQP RREPPREGLR
PPPYRPRRDA FEISTDGHSG PSNRDRAGPR GARSNNPRHP AFTAMGSSAP SYCQPITTVT
ASASVTVAVH PPPAPGPSSA WNPRGGLCPG YGDYPETDRG LFEDPHVPFN VRCERRDSKV
EVIELQDVEC EERPRGGSSN
//
