ID A0A452QQL9_URSAM Unreviewed; 1403 AA.
AC A0A452QQL9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Patched 1 {ECO:0000313|Ensembl:ENSUAMP00000007768.1};
GN Name=PTCH1 {ECO:0000313|Ensembl:ENSUAMP00000007768.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000007768.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000007768.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR Ensembl; ENSUAMT00000008768.1; ENSUAMP00000007768.1; ENSUAMG00000004488.1.
DR GeneTree; ENSGT00940000159011; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 431..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1019..1040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1046..1068
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1075..1101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1113..1133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1145..1170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 430..590
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1199
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1273..1294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1403 AA; 155695 MW; 3DC2437FE2ADC0CD CRC64;
XXXXXXXXGG SCSGAPGRPA GGGRRRRTGG LRRNAVLDRD YLHRPSYCDA AFALEQISKG
KATGRKAPLW LRAKFQRLLF KLGCYIQKNC GKFLVVGLLI FGAFAVGLKA ANLETNVEEL
WVEVGGRVSR ELNYTRQKIG EEAMFNPQLM IQTPKEEGAN VLTTEALRQH LDSALQASRV
HVYMYNRQWK LEHLCYKSGE LITETGYMDQ IIEYLYPCLI ITPLDCFWEG AKLQSGTAYL
LGKPPLQWTN FDPLEFLEEL KKINYQVDSW EEMLNKAEVG HGYMDRPCLN PADPDCPATA
PNKNATKPLD VALVLSGGCH GLSRKYMHWQ EELIVGGTVK NSTGKLVSAH ALQTMFQLMT
PKQMYEHFKG YEYVSHINWN EDKAAAILEA WQRTYVEVVH QSVTPNSTQQ VLSFTTTTLD
DILKSFSDVS VIRVASGYLL MLAYACLTML RWDCSKSQGA VGLAGVLLVA LSVAAGLGLC
SLIGISFNAA TTQVLPFLAL GVGVDDVFLL AHAFSETGQN KRIPFEDRTG ECLKRTGASV
ALTSISNVTA FFMAALIPIP ALRAFSLQAA VVVVFNFAMV LLIFPAILSM DLYRREDRRL
DIFCCFTSPC VSRVIQVEPQ AYTETHDNTR YSPPPPYSSH SFAHETQITM QSTVQLRTEY
DPHTHVYYTT AEPRSEISVQ PVTMTQDTLS CQSPESTSST RDLLSQFSDS SLHCLEPPCT
KWTLSSFAEK HYAPFLLKPK AKVVVIFLFL GLLGVSLYGT TRVRDGLDLT DIVPRETREY
DFIAAQFKYF SFYNMYIVTQ KADYPNIQHL LYDLHKSFSN VKYVMLEENK QLPKMWLHYF
RDWLQGLQDA FDSDWETGKI MPNNYKNGSD DGVLAYKLLV QTGSRDKPID ISQLTKRRLV
DADGIINPSA FYIYLTAWVS NDPVAYAASQ ANIRPHRPEW VHDKADYMPE TRLRIPAAEP
IEYAQFPFYL NGLRDTSDFV EAIEKVRTIC NNYTSLGLSS YPNGYPFLFW EQYIGLRHWL
LLSISVVLAC TFLVCAVFLL NPWTAGIIVT VLALMTVELF GMMGLIGIKL SAVPVVILIA
SVGIGVEFTV HVALAFLTAI GDKNRRAVLA LEHMFAPVLD GAVSTLLGVL MLAGSEFDFI
VRYFFAVLAI LTILGVLNGL VLLPVLLSFF GPYPEVSPAN GLNRLPTPSP EPPPSVVRFA
VPPGHANNGS DSSDSEYSSQ TTVSGISEEL RHYEAQQGTG GPAHQVIVEA TENPVFARST
VSHAGGTAPP RREPPREGLR PPPYRPRRDA FEISTDGHSG PSNRDRAGPR GARSNNPRHP
AFTAMGSSAP SYCQPITTVT ASASVTVAVH PPPAPGPSST DRGLFEDPHV PFNVRCERRD
SKVEVIELQD VECEERPRGG SSN
//
