ID A0A452QR83_URSAM Unreviewed; 822 AA.
AC A0A452QR83;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Neuronal PAS domain protein 2 {ECO:0000313|Ensembl:ENSUAMP00000008036.1};
GN Name=NPAS2 {ECO:0000313|Ensembl:ENSUAMP00000008036.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000008036.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000008036.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452QR83; -.
DR STRING; 9643.ENSUAMP00000008036; -.
DR Ensembl; ENSUAMT00000009078.1; ENSUAMP00000008036.1; ENSUAMG00000006874.1.
DR GeneTree; ENSGT00940000160744; -.
DR OMA; RPCRMPL; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR PANTHER; PTHR46055:SF1; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 13..63
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 86..149
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 264..311
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 407..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 822 AA; 91707 MW; 5161ECBA41AEC276 CRC64;
MKWNVPVTCV FCVYRASRNK SEKKRRDQFN VLIKELSSML PGNTRKMDKT TVLEKVIGFL
QKHNEVSAQT EICDIQQDWK PSFLSNEEFT QLMLEALDGF IIAVTTDGSI LYVSDSITPL
LGHLPSDVMD QNLLNFLPEQ EHSEVYKMLS SHMLVTDSPS PEYLKSDNDL EFYCHLLRGS
LNPKEFPTYE YIKFVGNFRS YNNVPSPSCN GFDSTLSRPC RVPLGKEVCF IATVRLATPQ
FLKEMCIVDE PLEEFTSRHS LEWKFLFLDH RAPPIIGYLP FEVLGTSGYD YYHIDDLELL
ARCHQHLMQF GKGKSCCYRF LTKGQQWIWL QTHYYITYHQ WNSKPEFIVC THSVVSYADV
RVERRQELAL EDPPPEAVHP SALKDKGSGL DCQQHFNALD VGTLGLNPSQ SPSVSSRSSH
KSSHTAMSEP TSTPSKRMAE ASTTALPRSA TLPQELPVLG LSQAATMPAP LPAPSSCDLT
QQLLPQTILQ SPSAPMTQFS AQFSMFQTIK DQLEQRTRIL QANIRWQQEE LHKIQEQLCL
VQDSNIQMFL QQPAVSLSFS SAPRPEAQQQ LQQRSAPGSQ PQLVASPQLP GQMGSAQVAN
QHLLRESSVI ATQGPRPMRS SQMMQGSGHS VSSLTPQFSS ATAVLPPALS LTTLASASQD
SSQCQPSPDF SHDRQLRLLL SQPIQPMMPG SCDARQPSEV SRTGRQVKYP QSQAVFPNAD
MRTTSSSTSP PVLLMGQAVP QASFPASRQS PLQPAQAQQQ PQHFLQVQAP TSLHSEQRDS
LLLSTYSQQP GTLGYPPPPQ PSRPPRRVSS LSESSGLQQP PR
//
