ID A0A452QRL3_URSAM Unreviewed; 860 AA.
AC A0A452QRL3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Adhesion G protein-coupled receptor D1 {ECO:0000313|Ensembl:ENSUAMP00000008198.1};
GN Name=ADGRD1 {ECO:0000313|Ensembl:ENSUAMP00000008198.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000008198.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000008198.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR AlphaFoldDB; A0A452QRL3; -.
DR Ensembl; ENSUAMT00000009251.1; ENSUAMP00000008198.1; ENSUAMG00000006975.1.
DR GeneTree; ENSGT00940000159783; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF216; ADHESION G-PROTEIN COUPLED RECEPTOR D1; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 568..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 772..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 565..796
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 860 AA; 94578 MW; 17344EB1B1E663FA CRC64;
SLWFEVLASA SHYWPLENVD GIHELQDTHG VLRAHNLTVL PSHNSTFVRT NDSAYSNFSA
TVDIVEGKVS KGIYLKEEKG VTLLYYGRYK ASCISSPAQC DPDGVTFSFF WKTQGEQSRP
TPFAYGGQVI SDGFRVGSSG GKGSVELYTR ENAMTWEATF SPPGPYWTHV LFTWKSKEGL
KVYVNGTLST SDPSGKVSHA YGEPSVNLVI GSEQDQTKRY EDGAFDEFII WERALTPDEI
SMYFTAAIGK HALLSSTPPS FFMTPPANTM PTNAYHPIII NLTETRKTFQ SPGTVLSYLR
NVSLKLPNKP LSQEMALNLT KVFLKTMEEV LQLPSWVDVS EDNAMVLGLI ETVDTVMGHI
SSNLDASKPQ VAIIGSSSMA EFSVAKLLPE TINSSHYRFP AQGQSYIEVP HEAFRSQAWT
TIVGLLYHRM HDYLDNIQPA KTKIPEAANY KNHKLSAASY LIALEVSPPP VLSQNLSGSP
LVTVQLRHRM SHRQRSEATN SSNQAFLYCA FLDFSSGEGV WSNQGCVLAE GNLSYSVCRC
THLTNFAILM QVVPMELTRG HKVALSSITY IGCSVSLVCL VLTLVTFAML SSVSTIRNQR
YHIHANLSFA VLVAQILLLV SFGFTPGTVP CRVMAMLLHY FFLSAFAWML VEGLHLYSMV
INVLCGKRYC LGSCSGWRCP VPLGGGTVVC WLSISSGAVW AFVAPALSII VVNVGILIAV
TRVISQISAD NYKIHGDPSA FKLTAKAVAV LLPILGTSWV FGVLALNSQA LVFQYIFAIL
NSLQGFFIFL FHCLLNSEVR AAFKHKTKVW TLTSSSARNT NVKPFSSDIM NGTRPGTVST
KLSPWDKSSH SAHRVDLSTV
//
